{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:21:21Z","timestamp":1790306481543,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011769","name":"St. Olavs Hospital Universitetssykehuset i Trondheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004590","name":"Helse Midt-Norge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009123","name":"Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted a population\u2010based study to assess the risk for multiple myeloma (MM) and other cancers in first\u2010 and second\u2010degree relatives of MM patients, and to investigate whether evidence of anticipation is present in familial MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved 24\u00a0845 first\u2010degree relatives and 41\u00a0008\u00a0second\u2010degree relatives of 7847\u00a0MM patients, and 86\u00a0984 first\u2010degree relatives, and 138\u00a0660\u00a0second\u2010degree relatives of 26\u00a0511\u00a0matched controls. A Cox model was used to assess the risk for MM and other cancers in relatives of MM patients. Anticipation was assessed by a Cox model, where all parents and offspring of MM patients were included in the risk set.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In second\u2010degree relatives of MM patients, no overall significant association with an MM diagnosis was observed (HR 1.99; 95%CI:0.86\u20134.57). In parents and offspring of MM patients, we found no significant difference in the ages at onset of MM (HR 1.28;95% CI:0.50\u20133.28). In affected parent\u2010offspring pairs, we observed no statistically significant difference in overall survival between the generations (HR 0.74; 95%CI:0.20\u20132.69).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, second\u2010degree relatives of MM patients were not associated with an increased risk for MM. Our study supports that genetic anticipation is not present in familial MM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13757","type":"journal-article","created":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T10:58:58Z","timestamp":1645354738000},"page":"486-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk of multiple myeloma and other malignancies among first\u2010 and second\u2010degree relatives of patients with multiple myeloma: A population\u2010based study"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-7086","authenticated-orcid":false,"given":"\u00d8ystein O.","family":"Langseth","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Hematology St. Olav\u2019s University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor \u00c5.","family":"Myklebust","sequence":"additional","affiliation":[{"name":"Department of Registration Cancer Registry of Norway  Oslo Norway"},{"name":"Department of Research and Innovation M\u00f8re and Romsdal Hospital Trust  \u00c5lesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom B.","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation M\u00f8re and Romsdal Hospital Trust  \u00c5lesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Hjertner","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Hematology St. Olav\u2019s University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Waage","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Hematology St. Olav\u2019s University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/5.2.132"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861201)58:11<2417::AID-CNCR2820581111>3.0.CO;2-S"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01061.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.19.1479"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.126"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708704"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21325"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-5-2-72"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"66","article-title":"Familiality of benign and malignant paraproteinemias. A population\u2010based cancer\u2010registry study of multiple myeloma families","volume":"90","author":"Ogmundsd\u00f3ttir HM","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20534"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0783"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0703-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051914"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2385::AID-CNCR13>3.0.CO;2-A"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.11.033"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21745"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24514"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.279"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14199"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc081677"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.037"},{"key":"e_1_2_10_23_1","unstructured":"AasbrennM LangmarkF Wisl\u00f8ffF.Er registreringen av myelomatose i Kreftregisteret god nok?2712\u20134. 2008."},{"issue":"26","key":"e_1_2_10_24_1","first-page":"2550","article-title":"Det sentrale folkeregister i medisinsk forskning","volume":"122","author":"Hammer H","year":"2002","journal-title":"Tidsskrift\u2010Norske Laegeforening"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6025"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2003.00111.x"}],"updated-by":[{"DOI":"10.1111\/ejh.13832","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000}}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:58:53Z","timestamp":1692871133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/ejh.13757"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13757","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/ejh.13832","asserted-by":"object"}]},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"assertion":[{"value":"2021-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}