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Pain and function were examined using the PROBE questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 49 participants [median age 44 (IQR 32, 52) years], most had severe haemophilia (Factor VIII\u00a0=\u00a030; Factor IX\u00a0=\u00a013) and were on regular prophylaxis (88%). Those with moderate haemophilia (Factor VIII\u00a0=\u00a05; Factor IX\u00a0=\u00a01) treated on demand (12%). Acute (72%) and chronic pain (71%), functional difficulties (58%), and analgesic requirements (92%) were prevalent. Age was significantly associated with more advanced haemophilic arthropathy (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), chronic pain (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.029) and functional difficulties (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.036). Adults who reported chronic pain commenced prophylaxis significantly later in life [32 (20, 51) vs. 8 (1, 23) years; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004]. Physical activity was significantly lower in those with functional difficulties (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). A disparity between self\u2010perceived \u2018target joints\u2019 and clinically defined target joints was also identified (76% vs. 23%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haemophilic arthropathy, pain and functional disability were prevalent amongst Irish adults with moderate and severe haemophilia. Age\u2010dependent lifestyle, analgesic and treatment influences on pain and function warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13763","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T11:08:07Z","timestamp":1646737687000},"page":"518-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-8022","authenticated-orcid":false,"given":"Megan","family":"Kennedy","sequence":"first","affiliation":[{"name":"Discipline of Physiotherapy Trinity Centre for Health Sciences Trinity College Dublin St. James\u2019s Hospital  Dublin 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