{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:23Z","timestamp":1790140583243,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This retrospective chart review examined real\u2010world healthcare resource utilization (HRU) in patients with AML ineligible for intensive therapy who received first\u2010line systemic therapy or best supportive care (BSC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected anonymously on patients with AML who initiated first\u2010line hypomethylating agents (HMA), low\u2010dose cytarabine (LDAC), other systemic therapy, or BSC. HRU endpoints included hospitalizations, outpatient consultations, transfusions, and supportive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1762 patients included, 46% received HMA, 11% received LDAC, 17% received other systemic therapy, 26% received BSC; median treatment durations were 118, 35, 33, and 57\u00a0days, respectively. Most patients were hospitalized, most commonly for treatment administration, transfusion, or infection (HMA 82%, LDAC 93%, other systemic therapy 83%, BSC 83%). A median number of hospitalizations were 2\u20136 across systemic groups and two for BSC, with median durations of 8\u201318\u00a0days. Transfusion rates and outpatient consultations were highest for HMA (80% and 79%) versus LDAC (57% and 53%), other systemic therapy (57% and 63%), and BSC (71% and 66%). Antivirals\/antibiotics and antifungals were used more frequently than growth factors (72\u201392%, 34\u201363%, and 7\u201327%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with AML ineligible for intensive therapy have high HRU; novel therapies are needed to alleviate this burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13769","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T13:24:45Z","timestamp":1647523485000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Healthcare resource utilization trends in patients with acute myeloid leukemia ineligible for intensive chemotherapy receiving first\u2010line systemic treatment or best supportive care: A multicenter international study"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-9156","authenticated-orcid":false,"given":"Tomoki","family":"Ito","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Kansai Medical University  Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sanford","sequence":"additional","affiliation":[{"name":"Leukemia\/Bone Marrow Transplant Program of BC Division of Hematology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-1519","authenticated-orcid":false,"given":"Ciprian","family":"Tomuleasa","sequence":"additional","affiliation":[{"name":"Department of Hematology Ion Chiricuta Clinical Cancer Center  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Hua","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Internal Medicine Kaohsiung Medical University Hospital and Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Jos\u00e9 Enciso","family":"Olivera","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cancerolog\u00eda  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Kumar","family":"Enjeti","sequence":"additional","affiliation":[{"name":"Calvary Mater Newcastle University of Newcastle  Waratah New South Wales Australia"},{"name":"NSW Health Pathology John Hunter Hospital  New Lambton Heights New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Gimenez","family":"Conca","sequence":"additional","affiliation":[{"name":"Section of Hematology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-513X","authenticated-orcid":false,"given":"Teresa Bernal","family":"del Castillo","sequence":"additional","affiliation":[{"name":"University Hospital Central de Asturias ISPA, IUOPA  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Girshova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Institution \u201cAlmazov National Medical Research Centre\u201d of the Ministry of Health of the Russian Federation  St Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery \u2013 Section of Hematology and Clinical Immunology Santa Maria della Misericordia\u201d Hospital Perugia University  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birol","family":"Guvenc","sequence":"additional","affiliation":[{"name":"Department of Hematology Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cat N.","family":"Bui","sequence":"additional","affiliation":[{"name":"AbbVie, Inc.  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