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Recent estimates of its incidence and trend over time were acquired for England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The primary ITP population (using ICD 10 code D693 and excluding secondary ITP cases; positive predictive value: 82.6%) was sourced from NHS Digital inpatient and outpatient. Incidence rate (IR) for England and by age groups, sex, and regions were calculated and trends were assessed using average annual percent change (AAPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25\u2009805 patients (mean age 59\u2009years; females 57.8%) diagnosed between 2003 and 2014 was identified. IRs increased from 4.2\/100\u2009000 to 6.4\/100\u2009000 over this period (AAPC:4.3%). For all sex\u2010specific age groups, the IRs significantly increased over time, except 18\u201329\u2009years males. The greatest increase was among females aged 30\u201339 (AAPC:8.7%). In contrast, among \u226570\u2009years, ITP was more common in males (highest IR among \u226580\u2009years males: 23.9\/100\u2009000). England's average annual IR was 6.1\/100\u2009000 for 2010\u201314. An estimated 2.5\/100\u2009000 (based on UKITP Registry data) was estimated to require 1st line treatment whereas 2.4\/100\u2009000 would have 1st and 2nd line treatments within 6\u00a0months from diagnosis. IRs for London and East Midlands were the highest (6.5\/100\u2009000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study found a rising incidence of primary ITP, with sharp increases among young women and elderly men. These findings put in context the impact of ITP on patients' lives and the healthcare services in England, especially with 17%\u201350% who may develop chronic ITP and require long\u2010term care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13803","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T08:23:28Z","timestamp":1654590208000},"page":"238-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incidence of adult primary immune thrombocytopenia in England\u2014An update"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-3792","authenticated-orcid":false,"given":"Indraraj Umesh","family":"Doobaree","sequence":"first","affiliation":[{"name":"Certara EVA  London 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