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The role of auto\u2010SCT in elderly patients older than 70\u2009years remains controversial in the era of novel agents and especially since the recent introduction of monoclonal antibodies (AbMo). In this study, we evaluated 12 patients with MM over 70\u2009years old undergoing auto\u2010SCT (elderly graft cohort) in seven centers of GIMEMA Working Group Lazio. We compared the baseline characteristics, treatment and outcome with 97\u2009MM elderly patients who did not receive auto\u2010SCT (nontransplant patients) from the same registry who were\u2009\u2265\u200970\u2009years old, but did not undergo auto\u2010SCT. The median progression free survival (PFS) for graft versus no\u2010graft cohort was 56.4 versus 26.1\u00a0months, respectively. There was a trend for better PFS among graft compared to nontransplant patient (p\u00a0=\u00a0.1). On the other hand, the median overall survival for transplant versus nontransplant cohort was 107.6 versus 49.5\u00a0months (p\u00a0=\u00a0.02). Despite the small number of patients aged \u226570\u2009years and\u2009\u226474\u2009years, it seems that auto\u2010SCT is well tolerated, safe and effective. Therefore, we propose that it should be considered an important treatment option in the era of new drugs in elderly fit patients with MM.<\/jats:p>","DOI":"10.1111\/ejh.13804","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T15:48:26Z","timestamp":1653580106000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autologous stem cell transplantation in multiple myeloma patients over 70\u2009years: A <scp>GIMEMA<\/scp> Lazio Working Group experience in a retrospective case\u2013control study"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-235X","authenticated-orcid":false,"given":"Angela","family":"Rago","sequence":"first","affiliation":[{"name":"ASL 1 UOSD Ematologia  Rome 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