{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:54:57Z","timestamp":1754110497890,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evidence about the cross\u2010talk between iron, glucose metabolism, and cardiac disease is increasing. We aimed to explore the link of pancreatic iron by Magnetic Resonance Imaging (MRI) with glucose metabolism and cardiac complications (CC) in sickle cell disease (SCD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We considered 70 SCD patients consecutively enrolled in the Extension\u2010Myocardial Iron Overload in Thalassemia Network. Iron overload was quantified by R2* technique and biventricular function by cine images. Macroscopic myocardial fibrosis was evaluated by late gadolinium enhancement technique. Glucose metabolism was assessed by the oral glucose tolerance test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with an altered glucose metabolism showed a significantly higher pancreas R2* than patients with normal glucose metabolism. Pancreatic siderosis emerged as a risk factor for the development of metabolic alterations (OddsRatio 8.25, 95%confidence intervals 1.51\u201345.1; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). Global pancreas R2* values were directly correlated with mean serum ferritin levels and liver iron concentration. Global pancreas R2* was not significantly associated with global heart R2* and macroscopic myocardial fibrosis. Patients with history of CC showed a significantly higher global pancreas R2* than patients with no CC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support the evaluation of pancreatic R2* by MRI in SCD patients to prevent the development of metabolic and cardiac disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13809","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T03:49:00Z","timestamp":1655005740000},"page":"289-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between pancreatic iron overload, glucose metabolism and cardiac complications in sickle cell disease: An Italian multicentre study"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5319-2769","authenticated-orcid":false,"given":"Laura","family":"Pistoia","sequence":"first","affiliation":[{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"},{"name":"U.O.C. Bioingegneria Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"All\u00f2","sequence":"additional","affiliation":[{"name":"Ematologia Microcitemia Ospedale San Giovanni di Dio \u2013 ASP Crotone  Crotone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Spasiano","sequence":"additional","affiliation":[{"name":"U.O.S.D. Malattie Rare del Globulo Rosso Azienda Ospedaliera di Rilievo Nazionale \u201cA. Cardarelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Messina","sequence":"additional","affiliation":[{"name":"Centro Microcitemie Grande Ospedale Metropolitano \"Bianchi\u2010Melacrino\u2010Morelli\"  Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"U.O.S. Day Hospital Talassemici Ospedale \"Sant'Eugenio\"\u2010 ASL Roma2  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Gamberini","sequence":"additional","affiliation":[{"name":"U. O. di Day Hospital della Talassemia e delle Emoglobinopatie. Dipartimento della Riproduzione e dell'Accrescimento Azienda Ospedaliero\u2010Universitaria \u201cS. Anna\u201d  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ermini","sequence":"additional","affiliation":[{"name":"S.O.S. Immunoematologia e Medicina Trasfusionale Ospedale S. Maria Annunziata  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Renne","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Cardioradiologia\u2010UTIC Presidio Ospedaliero \u201cGiovanni Paolo II\u201d  Lamezia Terme Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Fina","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Diagnostica per Immagini Ospedale \"Sandro Pertini\"  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Peritore","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Radiologia \"ARNAS\" Civico, Di Cristina Benfratelli  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Positano","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"},{"name":"U.O.C. Bioingegneria Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Medicine Institute of Radiology, University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"issue":"7","key":"e_1_2_8_2_1","first-page":"895","article-title":"Sickle cell disease in children","volume":"72","author":"Meier ER","year":"2012","journal-title":"Drugs"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1423-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13791"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06332.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15773"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0702"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553000903347880"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072637"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1121-7"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"385","article-title":"Evaluation of myocardial iron overload using cardiovascular magnetic resonance imaging","volume":"52","author":"Mavrogeni S","year":"2011","journal-title":"Hellenic J Cardiol"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"193","article-title":"A critical review of non invasive procedures for the evaluation of body iron burden in thalassemia major patients","volume":"6","author":"Maggio A","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0908"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12557"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08476.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20566"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21781"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5783-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22640"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.06.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22410"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1121"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-015-0522-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22417"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3982"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12296"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27169"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.025510"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000278"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829b2be6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2016.058"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430503"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e3282f20847"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.020"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-2-23"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21666"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22223"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.447"},{"issue":"6","key":"e_1_2_8_47_1","first-page":"527","article-title":"Relationship between oxidative stress, ferritin and insulin resistance in sickle cell disease","volume":"14","author":"Alsultan AI","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16596"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.25943.1"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235561"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23721"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5107589"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T09:28:01Z","timestamp":1692782881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/ejh.13809"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13809","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"assertion":[{"value":"2022-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}