{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:47:46Z","timestamp":1778942866434,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TR 1268\/3\u20101"],"award-info":[{"award-number":["TR 1268\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with hematologic disease are at high risk of morbidity and mortality from COVID\u201019 due to disease\u2010inherent and therapy\u2010related immunodeficiency. Whether infection with the SARS\u2010CoV2 omicron variant leads to attenuated disease severity in these patients is currently unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed clinical and laboratory parameters in 61 patients with underlying hematologic conditions with a SARS\u2010CoV2 omicron variant infection confirmed by nucleic acid amplification testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients reported symptoms of COVID\u201019, most commonly fatigue (37 patients, 60.66%) and cough (32 patients, 52.46%). 39.34% of patients reported fever. Dyspnea was reported by 10 patients and 7 patients (11.48%) required oxygen therapy. Anosmia and ageusia were relatively rare, occurring in less than 10% of patients. Severity of SARS\u2010CoV2 infection could be assessed in 60 patients. Five cases of critical illness leading to ICU admission occurred during the observation period. Overall mortality was 9.84% in this patient cohort, with heterogeneous causes of death. The majority of omicron\u2010infected hematologic patients experienced mild symptoms or remained asymptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this study, symptoms of COVID\u201019 tended to be milder than described for previous SARS\u2010CoV2 variants. However, the extent to which attenuated severity of omicron\u2010variant SARS\u2010CoV2 infection is caused by altered viral pathogenicity or pre\u2010existing host immunity cannot be inferred from our data and should be investigated in larger prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13818","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T09:54:13Z","timestamp":1656150853000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early report on the severity of <scp>COVID<\/scp>\u201019 in hematologic patients infected with the <scp>SARS\u2010CoV2<\/scp> omicron variant"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-2201","authenticated-orcid":false,"given":"Fabian","family":"Ullrich","sequence":"first","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation West German Cancer Center, University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Hanoun","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation West German Cancer Center, University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-3360","authenticated-orcid":false,"given":"Amin T.","family":"Turki","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation West German Cancer Center, University Hospital Essen, University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Liebregts","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation West German Cancer Center, University 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