{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:02:19Z","timestamp":1747184539859,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was carried out to assess the prognostic power of low CD49d expression (\u226510%) in newly diagnosed CLL patients using a previously described cohort. Eighty\u2010five patients were included. Median age at diagnosis; 70\u2009years (43\u201388); CD49d was expressed in 33\/85 (38.8%); 23\/33 (69.7%) at \u226530% referred to as \u2018HiCD49d\u2019 and 10\/33 (30.3%) between 10 and 30% with a bimodal pattern on scatterplot analysis referred to as \u2018LoCD49d\u2019. Eleven patients (12.9%) presented as Binet stage B, of whom 8 (72.7%) were CD49d+ (HiCD49d 7\/8; LoCD49d 1\/8). Seven of 81 patients (8.6%) were <jats:italic>NOTCH1<\/jats:italic> mutated and all were CD49d+ (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.01). IgVH analysis was performed on 29 (87.8%) of the CD49d+ cases, of whom 21 (72.4%) were unmutated and 8 (27.6%) were mutated. CD38+\/CD49d+ accounted for 11\/20 (55%) (CD38+\/HiCD49D: 9\/11; CD38+\/LoCD49D: 2\/11). At 42\u2009months, treatment had been initiated in 18\/85 (21%) patients, of these 10\/33 (30.3%) were CD49d+ versus 8\/52 (15.4%) of the CD49d\u2212 group. The median treatment free interval for the CD49d+ group was 11\u2009months (HiCD49d; 14.5\u00a0months, LoCD49d; 11\u2009months) compared to 21.5\u00a0months for the CD49d\u2212 group. These findings suggest that the predictive value of CD49d expression is retained at expression levels down to 10%.<\/jats:p>","DOI":"10.1111\/ejh.13824","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T17:17:35Z","timestamp":1656695855000},"page":"441-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low CD49d expression in newly diagnosed chronic lymphocytic leukaemia may be associated with high\u2010risk features and reduced treatment\u2010free\u2010intervals"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-3205","authenticated-orcid":false,"given":"Smyth","family":"Elizabeth","sequence":"first","affiliation":[{"name":"Department of Haematology Trinity St. James's Cancer Institute  Dublin 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