{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:45:04Z","timestamp":1754487904282,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to determine risk factors for iv iron infusion\u2010related reactions (IRR), and identify strategies for iron repletion after IRR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective chart review of patients treated in the classical hematology clinic at Yale Cancer Center (<jats:italic>n<\/jats:italic>\u00a0=\u00a0330 consecutive patients) from 2016 to 2021, who received iv ferumoxytol (60.3%), iron sucrose (14.8%), or iron dextran (10.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The iv iron IRR was noted in 58 (17.6%) patients, 62.1% of whom had previously tolerated iv iron. The severity of IRR was mild in 22, moderate in 23, and severe in 11 patients. Most (72.4%) patients who experienced IRR tolerated a subsequent iv iron infusion. On multivariable analysis, a history of non\u2010medication allergies was associated with greater odds of IRR (odds ratio [OR] 2.12, 95% confidence interval (CI): 1.16\u20133.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). No patients with type AB blood, and few with type A blood (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), had IRR; compared to type A or AB together, patients with type B (OR 5.00, 95% CI: 1.56\u201316.06, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) or type O (OR 3.71, 95% CI: 1.44\u20139.55, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) blood had greater odds of IRR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights a possible association of blood type with iv iron IRR; prospective studies with larger patient numbers are warranted to explore this association.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13838","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T17:57:44Z","timestamp":1658685464000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of iron infusion reactions with <scp>ABO<\/scp> blood type"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1172-2159","authenticated-orcid":false,"given":"Ayesha","family":"Butt","sequence":"first","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinatin","family":"Muradashvili","sequence":"additional","affiliation":[{"name":"Yale\u2010Waterbury Internal Medicine Residency Program Waterbury Hospital  Waterbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Soliman","sequence":"additional","affiliation":[{"name":"Yale\u2010Waterbury Internal Medicine Residency Program Waterbury Hospital  Waterbury Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyong","family":"Li","sequence":"additional","affiliation":[{"name":"Yale Center for Analytical Sciences Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne J.","family":"Burns","sequence":"additional","affiliation":[{"name":"Smilow Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Brooks","sequence":"additional","affiliation":[{"name":"Smilow Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Browning","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noffar","family":"Bar","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gena","family":"Borgman","sequence":"additional","affiliation":[{"name":"Smilow Hematology Yale New Haven Hospital  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Goshua","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Internal Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Health Policy and Management Harvard T.H. 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