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In the Danish General Suburban Population Study (<jats:italic>N<\/jats:italic>\u00a0=\u00a019\u2009958) from 2010 to 2013, 645 individuals were positive for <jats:italic>JAK2V617F<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u00a0613) or <jats:italic>CALR<\/jats:italic> (<jats:italic>N<\/jats:italic>\u00a0=\u00a032) mutations. Mutation\u2010positive individuals without haematological malignancy were defined as having CHIP (<jats:italic>N<\/jats:italic>\u00a0=\u00a0629). We used multiple and inverse probability weighted (IPW)\u2010adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>) by mutation status, variant allele frequency (VAF%), blood cell counts, and neutrophil\u2010to\u2010lymphocyte ratio (NLR). We performed 11\u2010year longitudinal follow\u2010up of eGFR in all individuals. Compared to CHIP\u2010negative individuals, the mean differences in eGFR were \u22125.6 (\u221210.3, \u22120.8, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) for <jats:italic>CALR<\/jats:italic>, \u221211.9 (\u221221.4, \u22122.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) for <jats:italic>CALR<\/jats:italic> type 2, and \u221210.1 (\u221218.1, \u22122.2, <jats:italic>p\u2009=<\/jats:italic>\u00a0.01) for <jats:italic>CALR<\/jats:italic> with VAF\u2009\u2265\u20091%. The IPW\u2010adjusted linear regression analyses showed similar results. NLR was negatively associated with eGFR. Individuals with <jats:italic>CALR<\/jats:italic> type 2 had a worse 11\u2010year longitudinal follow\u2010up on eGFR compared to CHIP\u2010negative individuals (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). In conclusion, individuals with <jats:italic>CALR<\/jats:italic> mutations, especially <jats:italic>CALR<\/jats:italic> type 2<jats:italic>,<\/jats:italic> had impaired kidney function compared to CHIP\u2010negative individuals as measured by a lower eGFR at baseline and during 11\u2010year follow\u2010up.<\/jats:p>","DOI":"10.1111\/ejh.13845","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T14:07:08Z","timestamp":1660313228000},"page":"576-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clonal haematopoiesis of indeterminate potential and impaired kidney function\u2014A Danish general population study with 11\u2009years follow\u2010up"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-5928","authenticated-orcid":false,"given":"Morten K.","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Haematology Zealand 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