{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:52:29Z","timestamp":1785786749281,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Dual\u2010energy X\u2010ray absorptiometry (DXA) remains the cornerstone for osteoporosis evaluation in Thalassemia major. However, several drawbacks have been observed in this unique setting. We sought to determine the correlation between quantitative CT (QCT) and DXA\u2010derived parameters; secondarily, we aimed to investigate the role of the two techniques in predicting the risk of fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included patients with \u03b2\u2010thalassemia major who had undergone both lumbar and femoral DXA examinations, and CT scans including the lumbar spine, performed for disparate diagnostic issues, within 4\u2009months from the DXA. CT data were examined employing a phantom\u2010less QCT method for bone mineral density (BMD) assessment. We also retrieved any spontaneous or fragility fractures occurring from 1\u2009year before up to 5\u2009years after the date of DXA scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 43 patients were included. QCT measures were significantly higher than those determined by DXA. The gap between QCT and DXA values was strongly associated with patient age. The most powerful predictive variable for risk of fracture was the ACR classification based on volumetric BMD obtained by QCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DXA provided more negative measures than those determined by QCT. However, QCT seemed to evaluate thalassaemic osteopathy better than DXA, since volumetric BMD was a stronger predictor of fracture.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13847","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T07:44:59Z","timestamp":1661327099000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of opportunistic quantitative computed tomography in the evaluation of bone disease and risk of fracture in thalassemia major"],"prefix":"10.1111","volume":"109","author":[{"given":"Aldo","family":"Carnevale","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, Section of Radiology University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Radiology University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bravi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Radiology University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rita","family":"Gamberini","sequence":"additional","affiliation":[{"name":"Unit of Thalassaemia and Haemoglobinopathies Day Hospital, Regional HUB Centre, Department of Medicine Azienda Ospedaliero\u2010Universitaria Sant'Anna  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology and Internal Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Reverberi","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service Azienda Ospedaliero\u2010Universitaria Sant'Anna  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Zatelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology and Internal Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchiore","family":"Giganti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Radiology University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology and Internal Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010010\u20101007\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2266"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3719-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223\u2010022\u201000963\u20103"},{"key":"e_1_2_9_7_1","volume-title":"Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)","author":"Cappellini MD","year":"2021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02003-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05212-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01623378"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001170050495"},{"key":"e_1_2_9_13_1","unstructured":"Am Coll Radiol Rest 2018 6 The American College of Radiology. 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