{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:58:24Z","timestamp":1793213904761,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune conditions in B\u2010cell lymphomas are frequent. Steroids are standard of care, but many patients require other immunosuppressive agents. Ibrutinib is a Bruton Tyrosine Kinase inhibitor that is approved for B\u2010cell indolent lymphoma treatment. We evaluated the use of ibrutinib in previously treated hematologic immune manifestations associated with B\u2010cell lymphomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We conducted a retrospective multicentric observational study. Patients presenting with active, relapsed\/refractory B\u2010cell lymphoma associated hematological immune manifestation (autoimmune cytopenia, acquired immune\u2010mediated bleeding disorders) were included. Twenty\u2010five patients were identified. Median age at ibrutinib introduction was 69\u2009years (range 44\u201384) and median number of previous treatment lines before ibrutinib was 2 (1\u20137). Twenty\u2010two patients (88%) were on concomitant stable treatment at inclusion. Within a median exposure of 8\u00a0months (2\u201335), overall response rate to ibrutinib on immune manifestations was 76% (95% CI, 54.9\u201390.6); complete response rate 44%. Fourteen patients (63%) were able to be weaned from concomitant treatments. Fourteen patients (56%) presented treatment\u2010related adverse events, mostly Grade 1 or 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ibrutinib in this setting provides good efficacy and safety profile. Clinical trials are needed to define subgroups of patients who will benefit from this strategy and establish its place in the therapeutic arsenal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13858","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T14:45:35Z","timestamp":1662043535000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ibrutinib as a treatment of hematologic autoimmune disorders in patients with indolent B\u2010cell lymphoma"],"prefix":"10.1111","volume":"109","author":[{"given":"Adrien","family":"Daniel","sequence":"first","affiliation":[{"name":"Department of Hematology Claude Huriez University Hospital  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ghez","sequence":"additional","affiliation":[{"name":"Department of Hematology and INSERM UMR1030 Gustave Roussy  Villejuif 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