{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:06:07Z","timestamp":1790665567562,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients with classical Hodgkin lymphoma (cHL) relapsing after second\u2010line therapy have a dismal prognosis and novel approaches are required for this patient group. Based on promising (pre\u2010)clinical data and the favourable toxicity profile, we performed a phase II clinical trial with the JAK inhibitor ruxolitinib in patients with relapsed or refractory cHL (r\/r cHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients \u226518\u2009years with histologically confirmed r\/r cHL who failed second\u2010line treatment were included. Ruxolitinib was given orally at a dose of 25\u2009mg twice daily in continuous 28\u2010day\u2009cycles until progression or unacceptable toxicity. Primary endpoint was the PET\/CT\u2010based overall response rate (ORR; complete response (CR) or partial response (PR)) after 2\u00a0cycles; secondary endpoints included progression\u2010free (PFS) and overall survival (OS) as well as feasibility. The Jericho Trial adopted a 2\u2010stage phase 2 design (Simon 1989).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 12 included patients in stage 1, 2 had a PR, 3 had a stable disease (SD) and 6 had progressive disease (PD) after two treatment cycles (ORR: 2\/12 evaluable patients, 16.7%). Median PFS was 3.6\u00a0months, the 1\u2010year OS estimate was 50.6% (median not reached). The toxicity profile was favourable with only one grade IV adverse event (7.1%) reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ruxolitinib exhibited a favourable side effect profile but modest activity in r\/r cHL. Although the formal stopping criterion after stage 1 was not met, the trial did not continue to stage 2 due to the low response and PFS rates observed in stage 1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13859","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T10:39:46Z","timestamp":1662201586000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["JAK inhibition with ruxolitinib in relapsed or refractory classical Hodgkin lymphoma: Final results of a phase II, open label, multicentre clinical trial (JeRiCHO)"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-3787","authenticated-orcid":false,"given":"Sarah","family":"Gillessen","sequence":"first","affiliation":[{"name":"German Hodgkin Study Group (GHSG), Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Pluetschow","sequence":"additional","affiliation":[{"name":"German Hodgkin Study Group (GHSG), Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladan","family":"Vucinic","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Munich  Munich 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Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Eichenauer","sequence":"additional","affiliation":[{"name":"German Hodgkin Study Group (GHSG), Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-8504","authenticated-orcid":false,"given":"Jan\u2010Michel","family":"Heger","sequence":"additional","affiliation":[{"name":"German Hodgkin Study Group (GHSG), Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf (CIO ABCD) Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne 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