{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:40:22Z","timestamp":1692506422393},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Given the complex pathology of sickle cell anemia (SCA) and low adherence to hydroxyurea (HU) treatment, there is a need to seek parameters that identify recent changes in patient status. The advanced clinical parameters (ACPs) allow an early analysis of hematopoiesis. We aimed to draw the demographic profile of non\u2010adherent SCA patients and to verify the use of ACPs as a measure of HU treatment adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a cross\u2010sectional study, we divided 83 SCA subjects treated with HU into Children (&lt;12\u2009years old) and adolescents\/adults (\u226512\u2009years old). Their hemogram with the ACPs, electronic medical charts and pharmacy claim data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010adherent \u226512\u2009years old patients had significantly increased WBC, absolute neutrophil, lymphocyte, monocyte, and basophil counts, RBC, RET, RDW, and PLT, and significantly decreased MCV and MCH. Subjects in the adolescent\/adult group with IG\u2020 \u22650.035 cells\/mm<jats:sup>3<\/jats:sup> had the RR for non\u2010adherence increased by 4.6 times (<jats:italic>p<\/jats:italic>\u00a0=\u2009.014), and the systemic immune inflammation index (SII) of non\u2010adherent patients was also significantly higher (<jats:italic>p<\/jats:italic>\u00a0=\u2009.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IG\u2020 presents clinical utility in early identification of non\u2010adherence to HU, especially when combined with other parameters, suggesting the evaluation of ACPs in laboratory routine, as they can be easily implemented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13860","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T14:49:35Z","timestamp":1662043775000},"page":"736-748","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced clinical parameters: A complementary hydroxyurea adherence evaluation in sickle cell anemia treatment"],"prefix":"10.1111","volume":"109","author":[{"given":"Isabela Delfino","family":"Moreira","sequence":"first","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carem Luana Machado","family":"Lessa","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gueverson Leonardo Gon\u00e7alves","family":"Rocha","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"},{"name":"Clinicas Hospital of Porto Alegre\/RS  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Dewes","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Undergraduate Program in Pharmacy Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Schmitt","family":"Jahnke","sequence":"additional","affiliation":[{"name":"Vale do Rio dos Sinos University (UNISINOS)  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Maria","family":"Fogliatto","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"},{"name":"Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Werlang","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liane Nanci","family":"Rotta","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre  Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1910.00050330050003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012838"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1814706"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26369"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-419879"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001701"},{"issue":"2","key":"e_1_2_9_13_1","first-page":"117","article-title":"An overview of the common methods used to measure treatment adherence","volume":"92","author":"Anghel LA","year":"2019","journal-title":"Med Pharm Rep"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.05.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2478\/jomb-2018-0052"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2344-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1678118"},{"key":"e_1_2_9_18_1","first-page":"8","volume-title":"Beyond a Better Box\u2014XN\u2010Series\u2122 Automated Hematology Analyzers","author":"Sysmex America Inc","year":"2016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.10.022"},{"key":"e_1_2_9_20_1","volume-title":"Medication Without Harm\u2014Global Patient Safety Challenge on Medication Safety","author":"World Health Organization","year":"2017"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02102-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0713-x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111464"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830320206"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322001"},{"key":"e_1_2_9_26_1","first-page":"216","volume-title":"Adherence to Long\u2010Term Therapies: Evidence for Action","author":"World Health Organization","year":"2003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.08.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-2027-x"},{"key":"e_1_2_9_29_1","first-page":"105","volume-title":"Pesquisa Nacional por Amostra de domic\u00edlios\u2014S\u00edntese de Indicadores 2015","author":"IBGE","year":"2015"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27721"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsv084"},{"key":"e_1_2_9_32_1","first-page":"26","volume-title":"Protocolo Cl\u00ednico e Diretrizes Terap\u00eauticas\u2014Doen\u00e7a Falciforme","author":"Minist\u00e9rio da Sa\u00fade do Brasil","year":"2018"},{"key":"e_1_2_9_33_1","first-page":"22","article-title":"Hydroxyurea treatment of sickle cell disease: towards a personalized model\u2010based approach","volume":"5","author":"Pandey A","year":"2021","journal-title":"J Transl Genet Genomics"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200709050-00001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04636-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.068965"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70233-R"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.598"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.08.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061697"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"issue":"1","key":"e_1_2_9_42_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229989"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2297"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-189012"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001807"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12990"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233700"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318274647d"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.15374"},{"issue":"2","key":"e_1_2_9_51_1","first-page":"10s","article-title":"Factors associated with low adherence to medicine treatment for chronic diseases in Brazil","volume":"50","author":"Tavares NU","year":"2016","journal-title":"Rev Saude Publica"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:21:46Z","timestamp":1692444106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/ejh.13860"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13860","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]},"assertion":[{"value":"2022-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}