{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:14:09Z","timestamp":1768421649338,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Despite the effectiveness of newer drugs for the treatment of multiple myeloma (MM), the outcomes are further improved by subsequent autologous stem cell transplantation (ASCT). Data on effectiveness in older patients are limited. We compared outcomes in patients aged 65\u201375\u2009years depending on whether they were treated with ASCT or not and compared those to outcomes in patients &lt;65\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, single\u2010center study. We compared progression\u2010free survival (PFS) and overall survival (OS) for all MM patients below and above the age of 65\u2009years treated \u00b1 ASCT at the Karolinska University Hospital between 2010 and 2020. PFS and OS were calculated by the Kaplan\u2013Meier method. Variables affecting PFS and OS were evaluated using Cox regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both PFS and OS were improved in the group 65\u201375\u2009years treated +ASCT compared to those treated pharmacologically (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). There were no significant differences between patients &lt;65\u2009years and those 65\u201375\u2009years treated with ASCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings indicate that even patients &gt;65\u2009years should be evaluated as candidates for ASCT. An individualized approach supported by a frailty\/geriatric assessment score could assist clinicians to select the appropriate treatment for each patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13861","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:45:13Z","timestamp":1662468313000},"page":"749-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Conditioning with melphalan 200 mg\/m<sup>2<\/sup> and subsequent <scp>ASCT<\/scp> improves progression\u2010free and overall survival in elderly myeloma patients compared to standard of care"],"prefix":"10.1111","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-535X","authenticated-orcid":false,"given":"Gabriel","family":"Afram","sequence":"first","affiliation":[{"name":"Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet  Stockholm 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