{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:37:51Z","timestamp":1775021871434,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The role of <jats:italic>Helicobater pylori<\/jats:italic> eradication in the treatment of high\u2010grade diffuse large B\u2010cell lymphoma (DLBCL) of the stomach is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review and meta\u2010analysis of currently available data. DLBCL\u2010remission rate after eradication therapy, post\u2010remission maintenance, and response rate in the case of additional oncological therapy were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By considering data of seven studies, the DLBCL remission was achieved in 81 (53.3%; 95% CI\u00a0=\u00a045.3\u201361.2) out of 152 <jats:italic>H.\u00a0pylori<\/jats:italic> eradicated patients. The regression rate did not differ between pure DLCBL and DLCBL with MALT component, between stage I and stage II disease, and between Caucasians and Asians. Disease regression was maintained in all patients after at a median of 63\u2009months (range: 46\u201329) follow\u2010up. In those non\u2010responders, DLBLC remission after additional chemo\u2010immunotherapy was achieved in 63 (98.4%; 95% CI\u00a0=\u00a095.4\u2013100) out of 64 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Data this systematic review suggest considering <jats:italic>H.\u00a0pylori<\/jats:italic> eradication as first\u2010line therapy to treat infected patients with early\u2010stage, high\u2010grade gastric lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13871","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T02:43:41Z","timestamp":1664505821000},"page":"643-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of <i>Helicobater pylori<\/i> eradication in patients with diffuse large B\u2010cell lymphoma of the stomach: A systematic review"],"prefix":"10.1111","volume":"109","author":[{"given":"Vincenzo","family":"De 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