{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:34:21Z","timestamp":1791650061926,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While significant evidence has established an increased rate of thrombosis in patients with cancer, the risk of occult malignancy in the setting of an unprovoked thrombosis is less clear. Despite continued interest in developing an effective screening system for occult malignancy following unprovoked venous thromboembolism (VTE), discrepancies in the literature and guideline recommendations leave providers uncertain whether to screen or perform further diagnostics for this patient population. Evidence suggests that screening for malignancy can detect cancer sooner in patients with unprovoked VTE, but there is a lack of high\u2010quality evidence demonstrating improvements in survival who receive early detection. In the following manuscript, we summarize VTE in relation to cancer epidemiology and pathophysiology. Our literature review summarizes the spectrum of testing strategies for occult malignancy following unprovoked VTE, including biomarker detection methods and various imaging approaches. We evaluate the benefit of additional diagnostic strategies, review current guidelines on the issue, and provide guidance to the reader on the best practice for investigating undiagnosed malignancy in patients with unprovoked VTE.<\/jats:p>","DOI":"10.1111\/ejh.13874","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T04:49:40Z","timestamp":1664858980000},"page":"24-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Screening for occult cancer after unprovoked venous thromboembolism: Assessing the current literature and future directions"],"prefix":"10.1111","volume":"110","author":[{"given":"Sarah S.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-0259","authenticated-orcid":false,"given":"Derrick","family":"Tao","sequence":"additional","affiliation":[{"name":"Providence Portland Medical Center, Earle A. Chiles Research Institute  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-1285","authenticated-orcid":false,"given":"Hannah S.","family":"McMurry","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-5976","authenticated-orcid":false,"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology School of Medicine, Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_19_2_1","first-page":"281","article-title":"Lectures on clinical medicine, delivered at the Hotel\u2010Dieu, Paris","volume":"5","author":"Trousseau A","year":"1865","journal-title":"J Echocardiogr"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-460121"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/acrefore\/9780190236557.013.130"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0119-2018"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02374.x"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10100380"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006209"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-1138"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804233381701"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-0868"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506623"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1782"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210153271604"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13842"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-019-01822-z"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605599"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2018.02.011"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-20315-3_2"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007488"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0043-5"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2019.303594"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-160321"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0917-4"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.41633"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-460139"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04754.x"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.06.026"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592335"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00480-5"},{"key":"e_1_2_19_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00720.x"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13547"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.10.042"},{"key":"e_1_2_19_34_1","unstructured":"Venous thromboembolic diseases: diagnosis management and thrombophilia testing. 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