{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133911,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report the final results of the 2\u2010year TAURUS study, assessing weekly prophylaxis dosing regimens of octocog alfa (Kovaltry\u00ae\/BAY 81\u20138973) used in standard clinical practice in patients with moderate\u2010to\u2010severe haemophilia A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TAURUS (NCT02830477) is a phase 4, multinational, prospective, non\u2010interventional, single\u2010arm study in patients of any age with moderate or severe haemophilia A (\u22645% factor [F]VIII activity). TAURUS was designed to primarily investigate weekly prophylaxis dosing regimens used in standard clinical practice. Annualised bleeding rates (ABRs), treatment satisfaction and adherence, and safety were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 302 patients included in the full analysis set, 84.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0255) maintained their octocog alfa prophylaxis baseline regimen throughout the study, with a majority of patients (76.5%,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0231) on two times or three times weekly regimens at the end of the observation period (\u22651\u2013\u22642\u2009years). ABRs, treatment satisfaction, and adherence remained stable during the observation period. Octocog alfa was well tolerated and there were no new or unexpected adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data show that a smooth transition is observed when switching to octocog alfa from a previous FVIII treatment, with no safety issues and stable bleeding rates in a real\u2010world setting of patients with moderate\u2010to\u2010severe haemophilia A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.13876","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:44:11Z","timestamp":1664844251000},"page":"77-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety in patients with haemophilia A switching to octocog alfa (\n                    <scp>BAY<\/scp>\n                    81\u20138973): Final results of the global real\u2010world study,\n                    <scp>TAURUS<\/scp>"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-447X","authenticated-orcid":false,"given":"Cristina","family":"Santoro","sequence":"first","affiliation":[{"name":"Hematology University Hospital, Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beng","family":"Fuh","sequence":"additional","affiliation":[{"name":"East Carolina University  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu Quoc","family":"Le","sequence":"additional","affiliation":[{"name":"Queen Fabiola Children's University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Maes","sequence":"additional","affiliation":[{"name":"University Hospital of Antwerp  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Berrueco","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u Barcelona University  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-855X","authenticated-orcid":false,"given":"Eva Maria","family":"Mingot\u2010Castellano","sequence":"additional","affiliation":[{"name":"Hospital Regional Universitario de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-0478","authenticated-orcid":false,"given":"Sylvia","family":"von Mackensen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tueckmantel","sequence":"additional","affiliation":[{"name":"Bayer  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Francisco","family":"Cabre\u2010Marquez","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Bayer  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_10_3_1","unstructured":"Orphanet.Hemophilia2009.https:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?Lng=GB&Expert=448."},{"key":"e_1_2_10_4_1","unstructured":"National Hemophilia Foundation.2021.https:\/\/www.hemophilia.org\/bleeding-disorders-az\/overview\/fast-facts."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04214.x"},{"key":"e_1_2_10_7_1","unstructured":"FDA.gov.Kovaltry prescribing information.2016.https:\/\/www.fda.gov\/media\/96221\/download"},{"key":"e_1_2_10_8_1","unstructured":"EMA.eu.Kovaltry summary of product 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