{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:35:59Z","timestamp":1793414159079,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We assessed the humoral and cellular response to the fourth BNT162b2 mRNA COVID\u201019 vaccine dose in patients with CLL. A total of 67 patients with CLL and 85 age matched controls tested for serologic response and pseudo\u2010neutralization assay. We also tested the functional T\u2010cell response by interferon gamma (IFN\u03b3) to spike protein in 26 patients. Two weeks after the fourth vaccine antibody serologic response was evident in 37 (55.2%) patients with CLL, 20 \/22 (91%) of treatment na\u00efve, and 9\/32 (28%) patients with ongoing therapy, compared with 100% serologic response in age matched controls. The antibody titer increased by 10\u2010fold in patients with CLL, however, still 88\u2010folds lower than age matched controls. Predictors of better chances of post fourth vaccination serologic response were previous positive serologies after second, third, and pre\u2010fourth vaccination, neutralizing assay, and treatment na\u00efve patients. T\u2010cell response improved from 42.3% before the fourth vaccine to 84.6% 2\u2009weeks afterwards. During the time period of 3\u2009months after the fourth vaccination, 14 patients (21%) developed COVID\u201019 infection, all recovered uneventfully. Our data demonstrate that fourth SARS\u2010CoV\u20102 vaccination improves serologic response in patients with CLL to a lesser extent than healthy controls and induces functional T\u2010cell response.<\/jats:p>","DOI":"10.1111\/ejh.13878","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T07:00:42Z","timestamp":1665212442000},"page":"99-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cellular and humoral response to the fourth BNT162b2 mRNA COVID\u201019 vaccine dose in patients with CLL"],"prefix":"10.1111","volume":"110","author":[{"given":"Ohad","family":"Benjamini","sequence":"first","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotem","family":"Gershon","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-8599","authenticated-orcid":false,"given":"Erez","family":"Bar\u2010Haim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Israel Institute for Biological Research  Ness\u2010Ziona Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaniv","family":"Lustig","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory Ministry of Health and Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics Israel Institute for Biological Research  Ness\u2010Ziona Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Doolman","sequence":"additional","affiliation":[{"name":"The Dworman Automated\u2010Mega Laboratory Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirav","family":"Kedmi","sequence":"additional","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"The Mina and Everard Goodman Faculty of Life Science Bar\u2010Ilan University  Ramat\u2010Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ribakovsky","sequence":"additional","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Kneller","sequence":"additional","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9072-7606","authenticated-orcid":false,"given":"Tammy","family":"Hod","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"Nephrology Department Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Erez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Israel Institute for Biological Research  Ness\u2010Ziona Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzhak","family":"Levy","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"The Infectious Disease Unit Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Rahav","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"},{"name":"The Infectious Disease Unit Chaim Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Avigdor","sequence":"additional","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Centre  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"https:\/\/coronavirus.jhu.edu\/map.html.2022."},{"issue":"20","key":"e_1_2_10_3_1","first-page":"1970","article-title":"BNT162b2 mRNA COVID\u201019 vaccine in a nationwide mass vaccination setting. 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