{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:04:11Z","timestamp":1751000651228},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01CA255721\u201001"],"award-info":[{"award-number":["1R01CA255721\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since 2003, more than 15 genes have been identified to predispose to hereditary hematologic malignancy (HHM). Although the yield of germline analysis for leukemia appears like that of solid tumors, genetic referrals in adults with leukemia remain underperformed. We assessed leukemia patients' attitudes toward genetic testing and leukemia\u2010related distress through a survey of 1093 patients diagnosed with acute or chronic leukemia, myelodysplastic syndrome, or aplastic anemia. Principal component analysis (PCA) was used to analyze patient attitudes. Distress was measured through the Impact of Event Scale\u2010Revised (IES\u2010R). Exactly 19.8% of eligible respondents completed the survey. The majority reported interest in (77%) or choosing to have (78%) genetic testing for HHM. Slightly over half identified worry about cost of genetic testing (58%) or health insurance coverage (61%) as possible barriers. PCA identified relevant themes of interest in genetic testing, impact on leukemia treatment, discrimination and confidentiality, psychosocial and familial impacts, and cost of testing. The majority reported low distress. Leukemia patients report high interest in genetic testing, few barriers, and relatively low distress.<\/jats:p>","DOI":"10.1111\/ejh.13880","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T13:58:57Z","timestamp":1665323937000},"page":"109-116","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing patient attitudes toward genetic testing for hereditary hematologic malignancy"],"prefix":"10.1111","volume":"110","author":[{"given":"Addison Q.","family":"Johnson","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Bannon","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"},{"name":"Department of Clinical Cancer Genetics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura S.","family":"Farach","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"},{"name":"Department of Pediatrics McGovern Medical School at UT Health  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel M.","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Clinical Cancer Genetics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Shahrukh","family":"Hashmi","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"},{"name":"Department of Pediatrics McGovern Medical School at UT Health  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Wagner","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences McGovern Medical School at UT Health  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney D.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences  Houston Texas USA"},{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120018821"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060838"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-695692"},{"key":"e_1_2_9_5_1","unstructured":"LarsonRA.Familial acute leukemia and myelodysplastic syndromes [Internet];2019. 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