{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:23:56Z","timestamp":1751466236621,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Polycythemia vera (PV) is an acquired clonal hematopoietic stem cell disorder characterized by the overproduction of red blood cells. It has long been underlined that there are differences in treatment patterns in routine practice. Therapeutic strategies have also expanded, and in recent years the JAK1\/JAK2 inhibitor ruxolitinib has emerged as a second\u2010line therapeutic option in patients who are intolerant to or resistant to hydroxyurea. Determining the impact of changes on practice patterns is of interest, especially for aspects that lack detailed guidance for management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To gain insights into treatment patterns by clinicians treating patients with PV in Italy, we carried out a survey of 60 hematologists and transfusion specialists. The questions covered: treatment of low\u2010risk patients, definition of significant leukocytosis, splenomegaly and excessive phlebotomies, resistance\/intolerance to hydroxyurea, use of ruxolitinib, cytoreductive therapy, and vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In general, the results of the survey indicate that there is a large heterogeneity in management of patients with PV across these areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While helping to provide greater understanding of treatment patterns for patients with PV in Italy, our survey highlights the need for additional clinical studies to obtain more precise guidance for the routine care of patients with PV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13889","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T02:53:06Z","timestamp":1667357586000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of polycythemia vera: A survey of treatment patterns in Italy"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-6319","authenticated-orcid":false,"given":"Giuseppe Alberto","family":"Palumbo","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate \u201cG.F. Ingrassia\u201d University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-6162","authenticated-orcid":false,"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology, Department of Precision and Translational Medicine, Policlinico Umberto 1 Sapienza University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Barat\u00e8","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Hematology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Hematology University of Verona and AOUI Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-5412","authenticated-orcid":false,"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[{"name":"Hematology Division and Bone Marrow Transplant Unit Ospedale San Gerardo, ASST Monza  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0812","authenticated-orcid":false,"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Hematology Division Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Novella","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Section of Hematology, Department of Radiological and Hematological Sciences Catholic University, Fondazione Policlinico A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Palandri","sequence":"additional","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1002\/ajh.26008"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.3109\/10428194.2013.813500"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1038\/leu.2013.163"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.amjmed.2004.06.032"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1182\/blood.2018834044"},{"key":"e_1_2_10_7_1","first-page":"166","volume-title":"Polycythemia Vera and the Myeloproliferative Disorders","author":"Berk PD","year":"1995"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"132","article-title":"Therapeutic recommendations in polycythemia vera based on polycythemia vera study group protocols","volume":"23","author":"Berk PD","year":"1986","journal-title":"Semin Hematol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1056\/NEJM198102193040801"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.2147\/TCRM.S213020"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1182\/blood.V99.4.1144"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1038\/nature03546"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1056\/NEJMoa051113"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1016\/j.ccr.2005.03.023"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.6004\/jnccn.2016.0133"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1182\/blood-2016-03-643544"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1016\/S1470-2045(16)30558-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1056\/NEJMoa1409002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1056\/NEJMoa1208500"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1007\/s00277-019-03847-z"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.3892\/etm.2021.10941"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1001\/jamanetworkopen.2019.12666"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1111\/ejh.13627"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1182\/bloodadvances.2019000211"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_1","DOI":"10.1182\/blood.2019003347"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_1","DOI":"10.1016\/j.clml.2019.11.010"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_1","DOI":"10.1016\/S2352-3026(22)00046-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_28_1","DOI":"10.1016\/j.clml.2019.09.601"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_1","DOI":"10.1182\/blood-2013-01-478891"},{"doi-asserted-by":"publisher","key":"e_1_2_10_30_1","DOI":"10.3390\/cancers12113132"},{"doi-asserted-by":"publisher","key":"e_1_2_10_31_1","DOI":"10.1016\/bs.ircmb.2021.02.008"},{"doi-asserted-by":"publisher","key":"e_1_2_10_32_1","DOI":"10.1186\/s40364-021-00298-5"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.13889","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.13889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:33:56Z","timestamp":1692635636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.13889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/ejh.13889"],"URL":"https:\/\/doi.org\/10.1111\/ejh.13889","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"type":"print","value":"0902-4441"},{"type":"electronic","value":"1600-0609"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"2022-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}