{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:32Z","timestamp":1787772392440,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Avascular necrosis (AVN) is a severe complication of sickle cell disease (SCD) and involves principally the femoral head. Few data exist about the prevalence of lesions in other segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 42 children (20 males and 22 females) underwent a magnetic resonance imaging (MRI) of the spine, upper arms, and femurs. The primary outcome was to define the prevalence and locations of bone infarcts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients completed the study; the total median age was 11.9\u2009years (interquartile range\u00a0=\u00a09.5\u201313.9). Eleven patients (26.2%) were positive for altered bone findings for a total of 32 lesions. Most of the lesions were in the humerus 17 (53.1%), 11 (34.4%) in the femurs, and 4 (12.5%) in the vertebrae. The median number of vaso\u2010occlusive crises (VOCs) was two and four for patients without and with bone lesions, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). The annual rate of VOC is the best marker for the positive MRI (odds ratio\u00a0=\u00a082.6; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03), and it is correlated with the number of sites involved (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study highlights that the prevalence of skeletal lesions could be underestimated, and it provides the basis for clinical reasoning and tailored therapy in SCD children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13898","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T13:43:14Z","timestamp":1668174194000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Occult ischemic bone lesions in children with sickle cell disease: A study of prevalence"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-2735","authenticated-orcid":false,"given":"Vincenzo","family":"Voi","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Science, School of Medicine, Centre for Hemoglobinopathies, AOU San Luigi Gonzaga University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Turrini","sequence":"additional","affiliation":[{"name":"Post\u2010graduating School, Pneumology, Citt\u00e0 della Salute e della Scienza, AOU Molinette University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"School of Medicine, AOU San Luigi Gonzaga University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vigliani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Science, School of Medicine, Centre for Hemoglobinopathies, AOU San Luigi Gonzaga University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Margarita","sequence":"additional","affiliation":[{"name":"C.D.C. 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