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Circulating endothelial activation and\/or apoptotic markers may reflect this endothelial activation\/damage that contributes to the pathophysiology of the SCD vascular complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasmatic levels of circulating endothelial cells (CECs), E\u2010selectin, progenitor's endothelial cells (EPCs), and circulating extracellular vesicles (EVs) were evaluated in 50 SCD patients, 16 with vasculopathy. The association between these markers and the occurrence of disease\u2010related microvascular injuries of the eye (retinopathy), kidney (nephropathy), and skin (chronic active ulcers) was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the endothelial activation markers studied, only higher plasma levels of E\u2010selectin were found in SCD patients with vasculopathy (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). Increased E\u2010selectin levels were associated with retinopathy (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but not with nephropathy or leg ulcers. All patients, at steady state, with or without vasculopathy, did not display a high count of CEC and EPC, markers of endothelial injury and repair. We did not show any significant differences in EVs levels between vasculopathy and not vasculopathy SCD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further studies will be required to determine whether the E\u2010selectin could be used as an early biomarker of retinopathy sickle cell development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13902","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T15:38:11Z","timestamp":1669045091000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasma levels of E\u2010selectin are associated with retinopathy in sickle cell disease"],"prefix":"10.1111","volume":"110","author":[{"given":"Imane","family":"Agouti","sequence":"first","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des syndromes dr\u00e9panocytaires majeurs, thalass\u00e9mies et autres pathologies rare du globule rouge et de l'\u00e9rythropo\u00ef\u00e8se Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Masson","sequence":"additional","affiliation":[{"name":"D\u00e9partement de m\u00e9decine interne, H\u00f4pital de la Timone Assistance Publique des H\u00f4pitaux de Marseille  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Loundou","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur les services de sant\u00e9 et la qualit\u00e9 de vie. 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