{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:54Z","timestamp":1787014134936,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T00:00:00Z","timestamp":1670112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007371","name":"Svend Andersen Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aetiology of multiple myeloma (MM) is unknown but various environmental exposures are suspected as risk factors. We present the first paper analysing the geographical distribution of MM in Denmark at the municipal level to investigate variations that could be explained by environmental exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with MM in Denmark during 2005\u20132020 were identified from nationwide registries and grouped into the 98 Danish municipalities based on residence. The age\u2010 and sex\u2010standardised incidence rate (SIR) of each municipality was compared to the national incidence in a funnel plot with 95% control limits. Differences in SIRs of rural, suburban, and urban areas were evaluated with incidence rate ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 5243\u2009MM patients were included. Overall, we found a heterogeneous geographical distribution of MM and a potential hotspot in southern Denmark. This hotspot contains three municipalities with SIRs above the 95% control limit assuming considerably higher rate of MM compared to the national incidence rate. A significant higher SIR was found in rural areas compared to urban areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The geographical distribution of MM in Denmark indicates that the risk of developing MM depends on place of residence probably due to environmental factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.13904","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T09:35:31Z","timestamp":1669109731000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Geographical and ecological analyses of multiple myeloma in Denmark: Identification of potential hotspot areas and impact of urbanisation"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-962X","authenticated-orcid":false,"given":"Lise Dueholm","family":"Bertelsen","sequence":"first","affiliation":[{"name":"Department of Haematology Clinical Cancer Research Centre, Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-8528","authenticated-orcid":false,"given":"Lars","family":"B\u00f8rty Nielsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Clinical Cancer Research Centre, Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-168X","authenticated-orcid":false,"given":"Heidi S\u00f8gaard","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT) Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-1814","authenticated-orcid":false,"given":"Martin","family":"B\u00f8gsted","sequence":"additional","affiliation":[{"name":"Department of Haematology Clinical Cancer Research Centre, Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Clinical Medicine, Center for Clinical Data Science (CLINDA) Aalborg University, and Research, Education and Innovation, Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Clinical Cancer Research Centre, Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Schou","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Haematology G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5477-746X","authenticated-orcid":false,"given":"Anja","family":"Klostergaard","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Iversen","family":"Schnack","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Hospital  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-7807","authenticated-orcid":false,"given":"Per Tr\u00f8llund","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Esbjerg Central Hospital  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-2014","authenticated-orcid":false,"given":"Niels","family":"Abildgaard","sequence":"additional","affiliation":[{"name":"Haematology Research Unit, Department of Haematology Odense University Hospital, and Department of Clinical Research, University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-5336","authenticated-orcid":false,"given":"Emil","family":"Hermansen","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-731X","authenticated-orcid":false,"given":"Annette Juul","family":"Vangsted","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen 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