{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:14:52Z","timestamp":1770912892853,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients with high\u2010risk hematologic diseases require intensive modalities, including high\u2010dose chemotherapy and allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Haploidentical T\u2010cell\u2013replete transplantation is a logical choice because of the limited availability of matched sibling donors and the prolonged time needed to identify matched unrelated donors in Thailand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical outcomes data of 43 patients undergoing allo\u2010HSCT were reviewed. All patients had high\u2010risk hematologic malignancies, were younger than 20\u2009years, and were in complete cytological remission at the time of allo\u2010HSCT. We used two different conditioning regimens: total body irradiation (TBI) combined with cyclophosphamide, fludarabine, and melphalan (<jats:italic>n<\/jats:italic>\u00a0=\u00a023) and thiotepa combined with fludarabine and busulfan (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). All patients received a graft\u2010versus\u2010host disease prophylaxis regimen consisting of cyclophosphamide, mycophenolate mofetil, and a calcineurin inhibitor or sirolimus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in engraftment between patients receiving either of the regimens. After a median follow\u2010up of 35.8 (range, 0.6\u2013106.2) months, the overall survival (OS) and event\u2010free survival (EFS) rates were 62.4% and 54.7%, respectively. OS and EFS were comparable between the respective regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that thiotepa\u2010based conditioning has similar efficacy and tolerability as TBI\u2010based conditioning for haploidentical HSCT with post\u2010transplant cyclophosphamide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13906","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:15:03Z","timestamp":1669896903000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effective T\u2010cell replete haploidentical stem cell transplantation for pediatric patients with high\u2010risk hematologic disorders"],"prefix":"10.1111","volume":"110","author":[{"given":"Supavich","family":"Tannumsaeung","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-7471","authenticated-orcid":false,"given":"Usanarat","family":"Anurathapan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samart","family":"Pakakasama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pongpak","family":"Pongpitcha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duantida","family":"Songdej","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nongnuch","family":"Sirachainan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Krung Thep Maha Nakhon (Bangkok) Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borje S.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suradej","family":"Hongeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine 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