{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:32Z","timestamp":1790352572628,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021510","name":"Department of Haematology, Christian Medical College, Vellore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monocytosis (\u22650.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L in peripheral blood) is the hallmark of chronic myelomonocytic leukaemia (CMML) but may be present in a spectrum of diseases including other haematological malignancies. In the primary care sector, monocytosis is a relatively common finding, but its predictive value for haematological malignancy is unknown. We included 663\u2009184 adult primary care patients from the greater Copenhagen area with one or more differential cell counts registered between 2000 and 2016 and followed them in the extensive nationwide Danish health data registers for 3\u2009years after blood sampling. We used logistic regression to model the risk of haematological malignancy and death following monocytosis. Monocytosis was associated with an increased risk of all types of haematological malignancy with the greatest relative risk increase observed in CMML with an OR of 105.22 (95% confidence interval: 38.27\u2013289.30). Sustained monocytosis (at least two requisitions in 3\u00a0months) further increased CMML risk, although the diagnosis was still very rare, that is, observed in only 0.1% of these individuals. Outside the haematological setting, the absolute risk of haematological malignancy associated with monocytosis is low and haematological malignancy should mainly be suspected when monocytosis is sustained or the clinical presentation raises suspicion of malignancy.<\/jats:p>","DOI":"10.1111\/ejh.13911","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T18:35:38Z","timestamp":1670438138000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monocytosis in primary care and risk of haematological malignancies"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8528-6671","authenticated-orcid":false,"given":"Mathilde Egelund","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Centre for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"Centre for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Kriegbaum","sequence":"additional","affiliation":[{"name":"Centre for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent Struer","family":"Lind","sequence":"additional","affiliation":[{"name":"Centre for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Copenhagen University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Samuelsson","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital Link\u00f6ping  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene Sofie Granfeldt","family":"\u00d8stg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Bio Research and Innovation Centre (BRIC) University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Centre for General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqy054"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00109"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-560227"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21721"},{"key":"e_1_2_10_9_1","first-page":"199","volume-title":"The Copenhagen Primary Care Differential Count (CopDiff) Database","author":"Andersen 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