{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133928,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Iron overload in patients with thalassemia represents a serious complication by affecting numerous organ systems. This meta\u2010analysis aims to establish an evidence regarding the effect of amlodipine on cardiac iron overload in thalassemia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Scopus, Web of Science, Cochrane Central, and EMBASE for all relevant randomized controlled trials (RCTs). The primary outcomes were cardiac T2* and myocardial iron concentration (MIC). Secondary outcomes were liver iron concentration (LIC), risk of Gastrointestinal (G.I.) upset and risk of lower limb edema. We used Hedges'\n                      <jats:italic>g<\/jats:italic>\n                      to pool continuous outcomes, while odds ratio was used for dichotomous outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven RCTs were eligible for this systematic review and meta\u2010analysis, comprising of 233 patients included in the analysis. Amlodipine had a statistically significant lower MIC (Hedges'\n                      <jats:italic>g<\/jats:italic>\n                      \u00a0=\u2009\u22120.82, 95% confidence interval [CI] [\u22121.40, \u22120.24],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.001) and higher cardiac T2* (Hedges'\n                      <jats:italic>g<\/jats:italic>\n                      \u00a0=\u20090.36, 95% CI [0.10, 0.62],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.03). Amlodipine was comparable to standard chelation therapy in terms of the risk of lower limb edema and GI upset.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our meta\u2010analysis found that amlodipine significantly increases cardiac T2* and decreases MIC, hence decreasing the incidence of cardiomyopathy\u2010related iron overload in thalassemia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.13919","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T08:37:40Z","timestamp":1671871060000},"page":"414-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of calcium channel blockers in preventing cardiac siderosis in thalassemia patients: An updated\n                    <scp>meta\u2010analysis<\/scp>\n      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E.","family":"Amer","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Faculty of Medicine Benha University  Banha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yomna Mohamed","family":"Goudy","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Faculty of Medicine South Valley University  Qena Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-0245","authenticated-orcid":false,"given":"Omar Ahmed","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Badawy","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Faculty of Medicine October 6 University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Adel","family":"Diab","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Medical Research Group of Egypt  Egypt"},{"name":"Department of Pediatrics, Hematology and Oncology Unit, Faculty of Medicine Alexandria University  Alexandria 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