{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:40:06Z","timestamp":1785516006027,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives and Methods<\/jats:title><jats:p>Venous thromboembolic (VTE) events are emerging as frequent complications in acute myeloid leukemia (AML); however, there is insufficient data regarding epidemiology, risk factors, and impact on outcomes. The optimal approach to balance risks of thrombosis and hemorrhage remains unclear. This retrospective single\u2010center study in AML patients undergoing induction chemotherapy between 2007 and 2018 assessed incidence, risk factors, features, and outcomes of early\u2010onset VTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>423 patients (median age 59\u2009years) were enrolled. VTE was diagnosed in 31 patients (7.3%) within 3\u00a0months of admission. The median time to VTE was 3\u2009days. Non\u2010central venous catheter (CVC)\u2010related VTE occurred in 19 patients (61%). Main risk factor for VTE was leukocytosis at admission, independent of platelet counts\/INR. Four patients (13%) exhibited VTE recurrence. No deaths directly related to VTE or major bleeding events associated with platelet\u2010adjusted anticoagulation in patients with VTE were recorded. There was no clear impact of VTE on 1\u2010year overall survival; however, non\u2010CVC\u2010related VTE may be associated with adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early\u2010onset VTE is a common complication in newly diagnosed AML patients admitted for induction chemotherapy. Leukocytosis is an independent VTE risk factor. The potentially adverse impact of non\u2010CVC\u2010related VTE merits further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13920","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T08:51:00Z","timestamp":1672131060000},"page":"426-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early\u2010onset venous thromboembolisms in newly diagnosed non\u2010promyelocytic acute myeloid leukemia patients undergoing intensive induction chemotherapy"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-1279","authenticated-orcid":false,"given":"Sebastian E.","family":"Koschade","sequence":"first","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology University Hospital Frankfurt, Goethe University  Frankfurt am Main 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