{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:25:11Z","timestamp":1760711111177,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thrombopoietin receptor agonists (TPO\u2010RAs) increase platelet counts (PC) in the majority of patients with chronic immune thrombocytopaenia (ITP). Platelet kinetics study (PKS) might contribute to the understanding of mechanisms that lead to durable response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of TPO\u2010RAs on PKS parameters in chronic ITP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen chronic ITP patients, aged 59\u2009years [range: 22\u201384], female\/male: 10\/5, splenectomised 7\/15, were treated with TPO\u2010RAs (eltrombopag\/romiplostim: 11\/4). Durable response was defined as PC \u226530\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L at 6\u00a0months. Autologous <jats:sup>111<\/jats:sup>Indium\u2010oxinate PKS was performed before and 5\u2009months after TPO\u2010RAs initiation. Accordingly, platelet survival (PS), platelet turnover, production ratio and sequestration site were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Durable response was achieved in 13\/15 of patients (eltrombopag\/romiplostim: 10\/3). Pre\u2010treatment parameters were: PC 10\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L [range: 1\u2013110], PS 0.5\u2009days [range: 0.1\u20131.7 (normal values: 7\u201310)], platelet turnover 30\u2009857 Plt\/\u03bcL\/day [range: 944\u2013103\u2009500] and platelet production ratio 0.64 [range: 0.01\u20133.2 (normal values: 1\u2009\u00b1\u20090.2)]. Post\u2010treatment assessment showed significantly higher: PC 92.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L [range: 28\u2013260, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001], PS 2.2\u2009days [range: 0.1\u20133.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008], platelet turnover 70\u2009213\u2009Plt\/\u03bcL\/day [range: 2800\u2013462\u2009236, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02] and platelet production ratio 1.8 [range: 0.5\u201337.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011] compared to the pre\u2010treatment values. Platelet sequestration site altered in 3\/15 treated with TPO\u2010RAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TPO\u2010RAs could increase PC by simultaneous increasing of platelet production and decreasing of platelet destruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13929","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T16:13:45Z","timestamp":1674144825000},"page":"548-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Platelet kinetics in patients with chronic immune thrombocytopaenia treated with thrombopoietin receptor agonists"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-7327","authenticated-orcid":false,"given":"Zlatko","family":"Pravdic","sequence":"first","affiliation":[{"name":"Clinic of Haematology University Clinical Centre of Serbia  Belgrade 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