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The primary objective was to identify the maximum tolerated dose (MTD) of wSKd. Secondary endpoints included overall response rate (ORR), progression\u2010free survival (PFS), and overall survival (OS). Prior exposure\/refractoriness to carfilzomib was permitted. Thirty patients were enrolled; 26 (87%) had triple\u2010class exposed disease and 6 (20%) received chimeric antigen receptor (CAR) T\u2010cell therapy. Dose level 2 (carfilzomib 70\u2009mg\/m<jats:sup>2<\/jats:sup> Intravenous [IV] on Days 1, 8, and 15; selinexor 100\u2009mg PO on Days 1, 8, 15, 22; dexamethasone 40\u2009mg on Days 1, 8, 15, 22 of 28\u2010day\u2009cycles) was chosen as the MTD, with no DLTs having occurred. The most common hematologic adverse events (AE) were thrombocytopenia (83%), anemia (70%), lymphopenia (50%), and neutropenia (50%). The most common nonhematologic AE were fatigue (70%), nausea (70%), diarrhea (53%), and anorexia (47%). The ORR was 21\/30 (70%) overall and 18\/23 (78%) at the MTD. At a median follow\u2010up of 12.3\u2009months, the median PFS was 5.3\u2009months and median OS 23.3\u2009months. Responses were similar in carfilzomib na\u00efve and exposed patients. Long\u2010term efficacy of wSKd is modest; wSKd could be employed as a bridging strategy to immunotherapies.<\/jats:p>","DOI":"10.1111\/ejh.13937","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:19:48Z","timestamp":1675315188000},"page":"564-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A phase I study of selinexor combined with weekly carfilzomib and dexamethasone in relapsed\/refractory multiple myeloma"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-1819","authenticated-orcid":false,"given":"Benjamin A","family":"Derman","sequence":"first","affiliation":[{"name":"Section of Hematology\/Oncology  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajai","family":"Chari","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-2795","authenticated-orcid":false,"given":"Jeffrey","family":"Zonder","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Karmanos Cancer Institute, Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-1335","authenticated-orcid":false,"given":"Ajay","family":"Major","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology  Chicago Illinois USA"},{"name":"Division of Hematology University of Colorado School of Medicine  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-3430","authenticated-orcid":false,"given":"Andrew T","family":"Stefka","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology  Chicago Illinois 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