{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T12:45:34Z","timestamp":1794573934192,"version":"4.9.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The outcomes of patients with acute lymphoblastic leukaemia (ALL) presenting relapse after allogeneic stem cell transplant (allo\u2010SCT) are poor, with few data available in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective and Methods<\/jats:title><jats:p>To evaluate the outcomes of patients with ALL presenting relapsed after allo\u2010SCT, we performed a retrospective study including 132 from 11 centres in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Therapeutic strategies consisted of palliative treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a022), chemotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a082), tyrosine kinase inhibitors (<jats:italic>n<\/jats:italic>\u00a0=\u00a026), immunotherapy with inotuzumab and\/or blinatumumab (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), donor lymphocyte infusions (<jats:italic>n<\/jats:italic>\u00a0=\u00a029 pts), second allo\u2010SCT (<jats:italic>n<\/jats:italic>\u00a0=\u00a037) and CAR T therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a014). The probability of overall survival (OS) at 1 and 5\u2009years after relapse was 44% (95% confidence interval [CI]: 36%; 52%) and 19% (95% CI: 11%; 27%). In the 37 patients undergoing a second allo\u2010SCT, the 5\u2010year estimated OS probability was 40% [22%; 58%]. Younger age, recent allo\u2010SCT, late relapse, 1st complete remission at 1st allo\u2010SCT and chronic graft\u2010versus\u2010host disease confirmed their positive impact on survival in the multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the poor prognosis of patients with ALL presenting relapse after a first allo\u2010SCT, some can be satisfactorily rescued and a second allo\u2010SCT still remains a valid option for selected patients. Moreover, emerging therapies really might improve ALL patients outcome when relapsing after an allo\u2010SCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13947","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T03:09:09Z","timestamp":1677121749000},"page":"659-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognosis of patients with acute lymphoblastic leukaemia relapsing after allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-5125","authenticated-orcid":false,"given":"Christelle","family":"Ferra Coll","sequence":"first","affiliation":[{"name":"Clinical Hematology Department, Institut Catal\u00e0 d'Oncologia, Institut de Recerca contra la Leucemia Josep Carreras, Hospital Germans Trias i Pujol. 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