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Flow cytometry characterized T\u2010cells in cryopreserved peripheral blood cells. Wilcoxon signed\u2010rank test compared physical function and T\u2010cell phenotype at baseline and 16\u2010weeks; Kendall's Tau assessed associations between variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Godin leisure\u2010time PA score increased from baseline to 16\u2010weeks (mean difference: 14.61, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and fatigue decreased (mean difference: 6.71, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). At baseline, lower fatigue correlated with a lower proportion of CD8+ T\u2010cells (<jats:italic>\u03c4<\/jats:italic>\u2009=\u20090.32, <jats:italic>p<\/jats:italic>\u2009=\u2009.03) and cardiorespiratory fitness (CRF) inversely correlated with the percentage of PD\u20101+CD8+ T\u2010cells (<jats:italic>\u03c4<\/jats:italic> \u22120.31, <jats:italic>p<\/jats:italic>\u2009=\u2009.03). At 16\u2010weeks, CRF inversely correlated with the proportion of PD\u20101+CD4+ T\u2010cells (<jats:italic>\u03c4<\/jats:italic> \u22120.34, <jats:italic>p<\/jats:italic>\u2009=\u2009.02). Reduced fatigue at 16\u2010weeks correlated with an increased CD4:CD8 ratio (<jats:italic>\u03c4<\/jats:italic>\u2009=\u20090.36, <jats:italic>p<\/jats:italic>\u2009=\u2009.02) and lower percentage of HLA\u2010DR+PD\u20101+CD4+ T\u2010cells (<jats:italic>\u03c4<\/jats:italic>\u2009=\u2009\u22120.37, <jats:italic>p<\/jats:italic>\u2009=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This intervention increased leisure\u2010time PA and decreased fatigue in CLL patients. These changes correlated with an increased CD4:CD8 T\u2010cell ratio and reduced proportion of T\u2010cells subsets previously associated with poor outcomes in CLL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier: NCT02194387.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13958","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T11:47:47Z","timestamp":1679485667000},"page":"732-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationships between T\u2010lymphocytes and physical function in adults with chronic lymphocytic leukemia: Results from the HEALTH4CLL pilot study"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-4412","authenticated-orcid":false,"given":"Justin C.","family":"Crane","sequence":"first","affiliation":[{"name":"Department of Health and Human Performance University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-4451","authenticated-orcid":false,"given":"Max J.","family":"Gordon","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-0646","authenticated-orcid":false,"given":"Karen","family":"Basen\u2010Engquist","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Behavioral Science, Division of Cancer Prevention and Population Services The University of 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