{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:15:08Z","timestamp":1777652108572,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019014","name":"Chengdu Science and Technology Program","doi-asserted-by":"publisher","award":["2022\u2010YF05\u201001444\u2010SN"],"award-info":[{"award-number":["2022\u2010YF05\u201001444\u2010SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502600"],"award-info":[{"award-number":["2022YFC2502600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are few large\u2010scale epidemiological and prognostic studies on blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its rarity. We used the Surveillance, Epidemiology, and End Results database to investigate the incidence, clinical characteristics, prognostic factors, and survival trends of BPDCN. The age\u2010adjusted incidence of BPDCN had a bimodal pattern with peaks in those under 20 and 60\u2009years and older. Of 697 patients, the median age at diagnosis was 31\u2009years. The most common primary sites were lymph nodes (59.4%), followed by bone marrow (17.1%) and skin (11.6%). Extranodal involvement (59.7%) was more common in patients aged 60\u2009years and older, while lymph node involvement was predominant in other age groups. The 1\u2010year, 3\u2010year, and 5\u2010year overall survival (OS) rates were 90.7%, 83.7%, and 82.3% in patients aged under 20, but dropped to 53.1%, 27.7%, and 20.0% in patients aged 60 and older. Multivariate Cox regression analysis revealed that age, sex, and first malignancy were independent prognostic factors for OS. Based on this regression model, a nomogram was built with high discrimination and calibration. The incidence, clinical characteristics, and prognosis of BPDCN patients vary by age group. Moreover, using the nomogram to predict OS can help guide individualized evaluations and clinical decisions.<\/jats:p>","DOI":"10.1111\/ejh.13959","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T08:48:40Z","timestamp":1679474920000},"page":"743-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Incidence, prognostic factors, and survival outcomes in patients with blastic plasmacytoid dendritic cell neoplasm: A retrospective study in the Surveillance, Epidemiology, and End Results database"],"prefix":"10.1111","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-3073","authenticated-orcid":false,"given":"Xiaojing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Haematology, West China Hospital Sichuan University  Chengdu Sichuan Province China"},{"name":"Department of Haematology Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Haematology, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Haematology, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Haematology, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Haematology, West China Hospital Sichuan University  Chengdu Sichuan Province 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