{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:49:43Z","timestamp":1781362183808,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asymptomatic neutropenia is a common hematology referral, though standardized reference ranges and published clinical outcomes are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our retrospective analysis, we evaluated demographics, laboratory, and clinical outcomes of adult patients referred to an academic hematology practice for evaluation of neutropenia from 2010 to 2018. Primary and secondary outcomes included incidence of hematologic disorders and rates of Duffy\u2010null positivity by race, respectively. In a separate analysis, we reviewed absolute neutrophil count (ANC) reference ranges from publicly available Association of American Medical Colleges Medical School Member laboratory directories to assess institutional variations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 163 patients were included, with disproportionate number of Black patients referred compared to local demographics. Twenty\u2010three percent of patients (<jats:italic>n<\/jats:italic>\u2009=\u200938) were found to have a clinically relevant hematologic outcome (mean ANC of 0.59\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), and only six were identified with ANC \u22651.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Incidence of hematologic outcomes was lowest among Black patients (<jats:italic>p<\/jats:italic>\u2009=\u2009.05), and nearly all Blacks who underwent Duffy\u2010null phenotype testing were positive (93%), compared to 50% of Whites (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). In separate review of laboratory directories, we confirmed wide variation in ANC lower limit of normal (0.91\u20132.40\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hematologic disorders were rare in patients with mild neutropenia and among Blacks, highlighting the need to standardize hematological ranges representative of non\u2010White communities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13963","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T08:49:59Z","timestamp":1679561399000},"page":"41-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes of patients referred for asymptomatic neutropenia: A focus on racial disparities in hematology"],"prefix":"10.1111","volume":"111","author":[{"given":"Emmanuella","family":"Oyogoa","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Oregon Health &amp; Science University, School of Medicine  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-4700","authenticated-orcid":false,"given":"Thomas","family":"DeLoughery","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-5976","authenticated-orcid":false,"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-8202","authenticated-orcid":false,"given":"Kylee L.","family":"Martens","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.485.3798522"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2018.38.6.503"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPN5BMTSF1CDYP"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102018\u20100059"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008600"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000528"},{"issue":"12","key":"e_1_2_12_8_1","first-page":"1271","article-title":"Familial leukopenia among Yemenite Jews","volume":"14","author":"Shoenfeld Y","year":"1978","journal-title":"Isr J Med Sci"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317751856"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/lc.1999.v133.a94931"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1265"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606113113"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27361"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2017.06.001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007679"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg073"},{"key":"e_1_2_12_17_1","first-page":"422a","article-title":"Benign neutropenia patients are subjected to frequent treatment delays when current treatment guidelines are used [abstract 1627]","volume":"18","author":"Lerma P","year":"1999","journal-title":"Proc ASCO"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15r10085"},{"key":"e_1_2_12_19_1","unstructured":"CBC with Differential.OHSU Lab Services. 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