{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:21:35Z","timestamp":1775438495428,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the safety, feasibility, and neuromuscular activity of acute low\u2010load resistance exercise with\/without blood flow restriction (BFR) in people with severe hemophilia (PwH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight PwH under prophylaxis (5 with resistance training experience) performed 6 randomly ordered conditions of 3 intensity\u2010matched knee extensions: no external load and no BFR, no external load and light BFR (20% of arterial occlusion pressure [AOP]), no external load and moderate BFR (40% AOP), external low load and no BFR, external low load with light BFR, and external low load with moderate BFR. Rated perceived exertion, pain, exercise tolerability, and adverse effects were assessed. Normalized root\u2010mean\u2010square (nRMS), nRMS spatial distribution, and muscle fiber\u2010conduction velocity (MFCV) were determined using high\u2010density surface electromyography for the vastus medialis and lateralis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exercises were tolerated, without pain increases or adverse events. Externally resisted conditions with\/without BFR provided greater nRMS than nonexternally resisted conditions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Spatial distribution and MFCV did not vary between conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In these patients, knee extensions with low external resistance and BFR at 20% or 40% AOP appear safe, feasible and do not cause acute\/delayed pain. However, BFR during three consecutive repetitions does not increase nRMS nor changes nRMS spatial distribution or MFCV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13965","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T10:29:17Z","timestamp":1679567357000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety, feasibility, and neuromuscular activity of acute low\u2010load resistance exercise with or without blood flow restriction in patients with severe hemophilia"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8346","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Calatayud","sequence":"first","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH\u2010RG), Department of Physiotherapy University of Valencia  Valencia 46010 Spain"},{"name":"National Research Centre for the Working 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