{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:39:36Z","timestamp":1754483976343,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the incidence of cardiotoxicity in patients with anthracycline exposure who subsequently receive EPOCH for non\u2010Hodgkin lymphoma (NHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study of adults with anthracycline exposure who subsequently received EPOCH for NHL at Memorial Sloan Kettering Cancer Center. The primary outcome was cumulative incidence of arrhythmia, heart failure (HF), left ventricular (LV) dysfunction, or cardiac death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 140 patients, most had diffuse large B\u2010cell lymphoma. Inclusive of EPOCH, median cumulative doxorubicin\u2010equivalent dose was 364\u2009mg\/m<jats:sup>2<\/jats:sup>; exposure was 400\u2009mg\/m<jats:sup>2<\/jats:sup> or higher in 41%. With median 36\u2010month follow\u2010up, 23 cardiac events were noted in 20 patients. Cumulative incidence of cardiac events at 60\u2009months was 15% (95% confidence interval [CI]: 9%\u201321%). When limited to LV dysfunction\/HF, cumulative incidence at 60\u2009months was 7% (95% CI: 3%\u201313%), with most events occurring after the first year. Univariate analysis indicated only history of cardiac disease and dyslipidemia to be associated with cardiotoxicity; no other risk factors, including cumulative anthracycline dose, were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective cohort, representing the largest experience in this setting with extended follow\u2010up, cumulative incidence of cardiac events was low. Rates of LV dysfunction or HF were particularly low, suggesting infusional administration may mitigate risk despite prior exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13971","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T09:12:54Z","timestamp":1679908374000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low incidence of cardiotoxicity in patients with <scp>non\u2010Hodgkin<\/scp> lymphoma receiving <scp>EPOCH<\/scp> after prior anthracycline exposure"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-1495","authenticated-orcid":false,"given":"Michael J.","family":"Buege","sequence":"first","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"},{"name":"Department of Pharmacy Practice University of Illinois\u2010Chicago College of Pharmacy, 833 S Wood Street  Chicago Illinois 60605 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-4538","authenticated-orcid":false,"given":"Esther","family":"Drill","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2006","authenticated-orcid":false,"given":"Steven M.","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4874-1417","authenticated-orcid":false,"given":"Andr\u00e9a","family":"LeVoir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-4557","authenticated-orcid":false,"given":"Terry","family":"Pak","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-859X","authenticated-orcid":false,"given":"Tim J.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-782X","authenticated-orcid":false,"given":"Phuong H.","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-3721","authenticated-orcid":false,"given":"Matthew J.","family":"Matasar","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center, 1275 York Avenue  New York New York 10018 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2001.26431"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.06.033"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-5-710"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-2-133"},{"key":"e_1_2_11_6_1","unstructured":"National Comprehensive Cancer Network.B\u2010Cell Lymphomas (Version 5.2021). 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