{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:50:40Z","timestamp":1784289040790,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with relapsed\/refractory diffuse large B\u2010cell lymphoma (R\/R DLBCL) have limited treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>R\/R DLBCL patients, who were mostly ineligible for ASCT due to age or comorbidities, were treated with maveropepimut\u2010S (MVP\u2010S, previously DPX\u2010Survivac) a survivin directed T cell educating therapy, pembrolizumab, and intermittent low\u2010dose cyclophosphamide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>We identified, using univariate analysis, a subset of patients with enhanced ORR, PFS and DOR. Patients with baseline CD20+\/PD\u2010L1 expression had an ORR of 46% (6\/13) and the disease control rate was 10\/13 (77%). The PFS and OS of the positive CD20+\/PD\u2010L1 patients were 7.1\u2009months and 17.4\u2009months, whereas in the intent\u2010to\u2010treat (ITT) population of 25 enrolled patients, the ORR was 28% (7\/25), median PFS and OS were 4.2\u2009months and 10.1\u2009months respectively. A total of 6\/7 clinical responders occurred in CD20+\/PD\u2010L1 patients. The regimen was well\u2010tolerated, requiring only minor dose modifications and one discontinuation. Grade 1 or 2 injection site reactions occurred in 14\/25, (56%). Statistically significant associations were also seen between PFS and; injection site reactions; and ELISpot response to survivin peptides, both identifying the mechanistic importance of specific immune responses to survivin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>This immunotherapy combination was found to be active and safe in this clinically challenging patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13982","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T06:16:46Z","timestamp":1683613006000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>PD\u2010L1<\/scp> expression predicts efficacy in the phase <scp>II SPiReL<\/scp> trial with <scp>MVP\u2010S<\/scp>, pembrolizumab, and low\u2010dose <scp>CPA<\/scp> in R\/R <scp>DLBCL<\/scp>"],"prefix":"10.1111","volume":"111","author":[{"given":"Irina","family":"Amitai","sequence":"first","affiliation":[{"name":"Sunnybrook Health Sciences Centre  Toronto Canada"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Roos","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iran","family":"Rashedi","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Mangoff","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute  Toronto 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