{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:17:00Z","timestamp":1772770620552,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["2020\u20101.1.6\u2010J\u00d6V\u0150\u20102021\u201000008"],"award-info":[{"award-number":["2020\u20101.1.6\u2010J\u00d6V\u0150\u20102021\u201000008"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>FA patients are hypersensitive to preconditioning of bone marrow transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assessment of the power of mitomycin C (MMC) test to assign FA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 195 patients with hematological disorders using spontaneous and two types of chromosomal breakage tests (MMC and bleomycin). In case of presumed Ataxia telangiectasia (AT), patients' blood was irradiated in vitro to determine the radiosensitivity of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients were diagnosed as having FA. The number of spontaneous chromosomal aberrations was significantly higher in FA patients than in aplastic anemia (AA) patients including chromatid breaks, exchanges, total aberrations, aberrant cells. MMC\u2010induced \u226510 break\/cell was 83.9\u2009\u00b1\u200911.4% in FA patients and 1.94\u2009\u00b1\u20090.41% in AA patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). The difference in bleomycin\u2010induced breaks\/cell was also significant: 2.01\u2009\u00b1\u20090.25 (FA) versus 1.30\u2009\u00b1\u20090.10 (AA) (<jats:italic>p<\/jats:italic>\u2009=\u2009.019). Seven patients showed increased radiation sensitivity. Both dicentric\u2009+\u2009ring, and total aberrations were significantly higher at 3 and 6\u2009Gy compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MMC and Bleomycin tests together proved to be more informative than MMC test alone for the diagnostic classification of AA patients, while in vitro irradiation tests could help detect radiosensitive\u2014as such, individuals with AT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.13990","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T06:33:58Z","timestamp":1684305238000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chromosomal breakage tests in the differential diagnosis of Fanconi anemia and aplastic anemia"],"prefix":"10.1111","volume":"111","author":[{"given":"Gy\u00f6ngyi","family":"Farkas","sequence":"first","affiliation":[{"name":"National Institute of 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