{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:16:22Z","timestamp":1790766982096,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Dysregulation of BCL\u20102 family members has been reported in acute lymphocytic leukemia (ALL), with various BH3\u2010dependencies of the leukemic clone. We conducted a multicenter retrospective cohort of patients with relapsed\/refractory B or T ALL, with ven\u2010chemotherapy or ven\u2010navitoclax combinations, to assess efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen patients were included in the analysis, median age was 32\u2009years, with 6 B\u2010ALL and 11 T\u2010ALL patients. Nine patients received venetoclax combined with chemotherapy, and 13 patients received venetoclax in combination with navitoclax, vincristine and asparaginase, of which 5 were already exposed to venetoclax in previous lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ORR was 55% and 46% among the ven\u2010chemotherapy and the ven\u2010navitoclax\u2010chemotherapy, respectively. Most of the responders proceeded to an allogenic bone marrow transplant in both cohorts. The most common adverse effects of the ven\u2010navitoclax combination were infectious complications and hepatotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data demonstrated the possible efficacy of ven\u2010chemotherapy and ven\u2010navitoclax in r\/r ALL with moderate toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14015","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T07:48:57Z","timestamp":1685519337000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Venetoclax\u2010based salvage therapy for adult patients with relapsed\/refractory acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-3524","authenticated-orcid":false,"given":"Jonathan","family":"Canaani","sequence":"first","affiliation":[{"name":"Hematology Division Chaim Sheba Medical Center, Faculty of Medicine, Tel Aviv University  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Frisch","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Rambam Health Care Campus, and Rappaport Faculty of Medicine, Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Pollyea","sequence":"additional","affiliation":[{"name":"Division of Hematology School of Medicine, University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Hematology School of Medicine, University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomzion","family":"Aumann","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-4807","authenticated-orcid":false,"given":"Chezi","family":"Ganzel","sequence":"additional","affiliation":[{"name":"The Hematology Department, Shaare Zedek Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine Hebrew University of Jerusalem, Israel  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-3746","authenticated-orcid":false,"given":"Arnon","family":"Haran","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa Gross","family":"Even\u2010Zohar","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Medical Center and 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