{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133922,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010306","name":"Direkt\u00f8r Kurt B\u00f8nnelycke og Hustru fru Grethe B\u00f8nnelyckes Fond","doi-asserted-by":"publisher","award":["10053\u2010030"],"award-info":[{"award-number":["10053\u2010030"]}],"id":[{"id":"10.13039\/501100010306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010347","name":"Fabrikant Einar Willumsens Mindelegat","doi-asserted-by":"publisher","award":["20844469"],"award-info":[{"award-number":["20844469"]}],"id":[{"id":"10.13039\/501100010347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008239","name":"Trigon Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Patients with Philadelphia\u2010negative myeloproliferative neoplasms (MPNs) have a higher burden of cardiac calcifications compared to the general population. It is not known whether the\n JAK2V617F<\/jats:italic>\n mutation is associated with increased cardiac calcification.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To investigate if a higher\n JAK2V617F<\/jats:italic>\n variant allele frequency (\n VAF<\/jats:italic>\n ) is associated with severe coronary atherosclerosis and the presence of aortic valve calcification (AVC).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with MPNs were examined by cardiac computer tomography to establish coronary artery calcium score (CACS) and AVC score. The first\n VAF<\/jats:italic>\n after diagnosis was registered. Severe coronary atherosclerosis was defined as a CACS >400 and AVC was defined as an AVC score >0.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 161 patients, 137 were\n JAK2V617F<\/jats:italic>\n mutation\u2010positive, with a median\n VAF<\/jats:italic>\n of 26% (interquartile range 12%\u201352%). A\n VAF<\/jats:italic>\n in the upper quartile range was associated with a CACS >400 [odds ratio (OR) 15.96, 95% confidence interval [CI] 2.13\u2013119.53,\n p<\/jats:italic>\n \u2009=\u2009.0070], after adjustment for cardiovascular risk factors and MPN subtype. An association was not found for the presence of AVC (OR 2.30, 95% CI 0.47\u201311.33,\n p<\/jats:italic>\n \u2009=\u20090.31).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In patients with MPNs, there is a significant association between having a\n VAF<\/jats:italic>\n in the upper quartile (>52%), and severe coronary atherosclerosis, defined as a CACS >400. The presence of AVC is not associated with\n VAF<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ejh.14019","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:37:42Z","timestamp":1686184662000},"page":"400-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["High\n JAK2V617F variant allele frequency<\/i>\n is associated with coronary artery but not aortic valve calcifications in patients with Philadelphia\u2010negative myeloproliferative neoplasms"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-9083","authenticated-orcid":false,"given":"Camilla Nordheim","family":"Solli","sequence":"first","affiliation":[{"name":"Department of Cardiology Zealand University Hospital Roskilde Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 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