{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:43:59Z","timestamp":1789494239594,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:00:00Z","timestamp":1685836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970106"],"award-info":[{"award-number":["81970106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare cyclosporine (CSA) combining eltrombopag (EPAG) with or without antithymocyte globulin (ATG) in aplastic anemia (AA) patients in the real world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AA patients who received ATG combining CSA and EPAG (Group A) and CSA\u2009+\u2009EPAG (Group B) as front\u2010line treatment in 13 medical centers in China were enrolled. The efficacy and safety were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 89 patients were enrolled with 51 patients in Group A and 38 patients in Group B. The 6\u2010month overall response (OR)\/complete response (CR) was 73.3%\/24.4% and 60.6%\/27.3% in Groups A and B (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.1). For severe AA patients, the 6\u2010month OR was 74.1% versus 50% and 6\u2010month CR was 25.9% versus 20% in Groups A and B (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.1). Multivariate analysis showed gender affects the 6\u2010month OR with females better OR (<jats:italic>p<\/jats:italic>\u2009=\u2009.017, OR 6.045, 95% CI: 1.377\u201326.546) and time from disease onset to treatment affected the 12\u2010month CR (<jats:italic>p<\/jats:italic>\u2009=\u2009.026, OR 0.263, 95% CI: 0.081\u20130.852). No difference was found in side effects except ATG infusion reaction and serum sickness. Mortality was 7.8% in Group A and no patient died in Group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CSA\u2009+\u2009EPAG had a similar response and less side effects compared with standard immunosuppressive therapy\u2009+\u2009EPAG in newly diagnosed AA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14021","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T01:03:15Z","timestamp":1686013395000},"page":"407-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cyclosporine plus eltrombopag in the treatment of aplastic anemia with or without antithymocyte immunoglobulin: A multicenter real\u2010world retrospective study"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8002-6651","authenticated-orcid":false,"given":"Miao","family":"Chen","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital (PUMCH) Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchi","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Suo","sequence":"additional","affiliation":[{"name":"HanDan Central Hospital  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Ding","sequence":"additional","affiliation":[{"name":"Dongfang Hospital Beijing University of Chinese Medicine  Beijing 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