{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:48:04Z","timestamp":1788504484466,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R327\u2010A18949"],"award-info":[{"award-number":["R327\u2010A18949"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of relapsed or refractory (R\/R) acute myeloid leukaemia (AML) remains challenging and outcomes extremely poor. The introduction of venetoclax has transformed the treatment of AML and emerging data suggest that venetoclax\u2010based therapy may enforce salvage treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this nationwide Danish retrospective study, we analysed treatment outcomes of venetoclax\u2010based salvage treatment for R\/R AML between 2019 and 2022. Only venetoclax\u2010naive patients who had previously received treatment with intensive chemotherapy therapy were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 43 R\/R patients with a median age of 57\u2009years. Nine (20.9%) were primary refractory and 34 (79.1%) patients had relapsed, including 21 after previous allogeneic stem cell transplantation. The overall response rate was 76.2% including 61.9% with composite complete remission (CRc: CR\u2009+\u2009CRi). Among CRc\u2010responders with information on measurable residual disease (MRD), 8\/13 (61.5%) obtained an MRD\u2010negativity response. The overall survival was 9.3\u2009months for all patients with an estimated 1\u2010year overall survival of 34%. For CRc\u2010responders the median overall survival was 13.3\u2009months, and the median relapse\u2010free survival was 12.8\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Venetoclax\u2010based salvage treatment for R\/R AML produced high response rates; however, for most patients the response was of limited duration. This study is limited by an observational design and prone to selection bias.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14046","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T07:59:02Z","timestamp":1690271942000},"page":"573-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Venetoclax\u2010based therapy for relapsed or refractory acute myeloid leukaemia following intensive induction chemotherapy"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-7051","authenticated-orcid":false,"given":"Daniel Tuyet","family":"Kristensen","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Centre Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg 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