{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:57:07Z","timestamp":1791493027405,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003463","name":"Haematology Society of Australia and New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015675","name":"National Blood Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to describe the burden of thrombocytopenia, supportive care practices, bleeding complications and predictors of bleeding in MDS patients within a large Australian hospital network, to better understand the use and effectiveness of platelet transfusions in MDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of patients aged \u226518\u2009years with MDS, chronic myelomonocytic leukaemia or MDS\/myeloproliferative overlap neoplasm admitted from 2016 to 2018 was conducted. Data were obtained from hospital medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010nine patients (median age 78\u2009years, 61.5% male) were identified. The median platelet count at first admission was 90\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Twenty\u2010eight (15.6%) patients had severe thrombocytopenia (platelet count &lt;20\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), of whom nine (32.1%) received prophylactic platelet transfusions, five (17.9%) received tranexamic acid (TXA), seven (25%) received both platelet transfusions and TXA, and seven (25%) received no treatment. Bleeding events requiring hospitalisation occurred in 20 (11.2%) patients. Bleeding was not predicted by presenting platelet count, TXA use, platelet transfusion or anticoagulant\/antiplatelet therapies. Three patients died of bleeding, at varying platelet counts (18, 38 and 153 \u00d7\u200910<jats:sup>9<\/jats:sup>\/L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thrombocytopenia is common in MDS. Although guidelines recommend otherwise, prophylactic platelet transfusions were commonly used for severe thrombocytopenia. Despite the majority of patients receiving platelet transfusions and\/or TXA, 11% developed major bleeding occurring at a wide range of platelet counts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14049","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T08:24:00Z","timestamp":1689409440000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Platelet transfusions and predictors of bleeding in patients with myelodysplastic syndromes"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-3133","authenticated-orcid":false,"given":"Allison","family":"Mo","sequence":"first","affiliation":[{"name":"Transfusion Research Unit, School of Public Health &amp; Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Monash Haematology Monash Health  Melbourne Victoria Australia"},{"name":"Austin Pathology and Department 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