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Currently, two CAR T cell products\u2014idecabtagene vicleucel and ciltacabtagene autoleucel\u2014are approved in the United States and the European Union to treat patients with three prior lines of therapy, including a proteasome inhibitor, an immunomodulatory drug, and an anti\u2010CD38 antibody. Moreover, seminal phase III trials of both agents in earlier lines of therapy have been published recently. Despite unprecedented rates of deep and lasting remissions in RRMM, there are still areas of uncertainty regarding the optimal use and distribution of CAR T cells in multiple myeloma. In the current review, we discuss the available data on approved CAR T cell products as well as unmet clinical needs and ongoing developments to optimize usage of this promising treatment modality in multiple myeloma.<\/jats:p>","DOI":"10.1111\/ejh.14051","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T08:39:34Z","timestamp":1691397574000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>CAR<\/scp> T cell therapy in multiple myeloma, where are we now and where are we heading for?"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3619-2958","authenticated-orcid":false,"given":"Luise","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Hematology, Cellular Therapy, Hemostaseology and Infectiology University Hospital of Leipzig  Leipzig 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