{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:39:58Z","timestamp":1765233598915,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003018","name":"Institute for Myeloma and Bone Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Isatuximab is approved for treatment of relapsed\/refractory multiple myeloma (RRMM) with dexamethasone and carfilzomib or pomalidomide. Patients receiving these three\u2010drug regimens have exhibited more Grade\u2009\u2265\u20093 adverse events (AEs) compared to the two\u2010drug class combination of isatuximab and steroids alone. Thus, this single\u2010center retrospective study investigated the efficacy of isatuximab with dexamethasone and methylprednisolone (ISAdm) for RRMM patients showing only biochemical progression (BP) of their disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four RRMM patients exhibiting only BP were administered isatuximab at 10\u2009mg\/kg with dexamethasone once weekly for cycle 1 of a 28\u2010day\u2009cycle, followed by every other week for each cycle thereafter. Starting in cycle 2, oral methylprednisolone was added every other day stopping 48\u2009h before and starting 48\u2009h after each dexamethasone infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall response rate and clinical benefit rate were 63% and 79%, respectively. Progression free survival was 12.9\u2009months. There were only 5 AEs of Grade\u2009\u2265\u20093 which included lymphocytopenia (13%), leukopenia (4%), and neutropenia (4%). No Grade\u2009\u2265\u20093 AE related to respiratory infection, anemia, or thrombocytopenia were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that the two\u2010drug class combination of ISAdm is an effective and well tolerated treatment option for RRMM patients exhibiting only BP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14057","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T07:30:16Z","timestamp":1690183816000},"page":"628-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of isatuximab in combination with steroids for the treatment of relapsed\/refractory multiple myeloma patients exhibiting only biochemical progression\u2014A single center retrospective study"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7797-7026","authenticated-orcid":false,"given":"Bernard 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