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Second generation chimeric antigen receptors (CAR) incorporating co\u2010stimulatory molecules like 4\u20101BB or CD28 were able to overcome some of the hindrances with initial CAR constructs resulting in efficacious products. Many second\u2010generation CAR\u2010T products have been approved in the treatment of relapsed\/refractory hematologic malignancies including multiple myeloma (MM), non\u2010Hodgkin lymphoma (NHL), and acute lymphoblastic leukemia. However, challenges remain in optimizing the manufacturing, timely access, limiting the toxicity from CAR\u2010T infusions and improving sustainability of responses derived with CAR\u2010T therapy. 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