{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:40:58Z","timestamp":1786430458101,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA\u2010matched sibling is currently the standard of care. Haploidentical HSCT from a family donor with a TCR \u03b1\u03b2\/CD19 depleted graft (T\u2010haplo) is an increasingly successful alternative, which requires the generation of G\u2010CSF stimulated peripheral stem cell (PBSC) from haploidentical relatives. These sickle cell trait (SCT) donors reported to develop SCD\u2010related complications in conditions of severe stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective analysis, we compared the safety and efficacy of PBSC mobilization with a G\u2010CSF intensified mobilization regimen in SCT donors with a conventional G\u2010CSF mobilization regimen in healthy donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reported adverse events were similar during intensified G\u2010CSF mobilization, apheresis, and shortly after stem cell apheresis in SCT and control donors. In SCT and control donors, we were able to mobilize high yields of CD34<jats:sup>+<\/jats:sup> stem cells and the harvested CD34<jats:sup>+<\/jats:sup> cell count was comparable with control donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripheral stem cell mobilization using an intensified G\u2010CSF regimen is safe, and well tolerated among SCT donors. SCT donors are a valid alternative for collection of peripheral CD34<jats:sup>+<\/jats:sup> stem cells for T\u2010cell\u2010depleted haploidentical stem cell transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14083","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:03:51Z","timestamp":1693188231000},"page":"824-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G\u2010CSF regimen"],"prefix":"10.1111","volume":"111","author":[{"given":"Morad","family":"Mohrez","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry and Laboratory Medicine, Transfusion Medicine University Hospital Regensburg  Regensburg 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