{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:37:12Z","timestamp":1785854232822,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Chlorhexidine gluconate (CHG)\u2010coated gel pad dressings for central venous catheter (CVC) may prevent CVC\u2010related bloodstream infections (CRBSI). However, real\u2010world data showing beneficial effects in patients with hematologic malignancies are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a matched\u2010pair analysis with data from a multicenter CVC registry, non\u2010tunneled jugular and subclavian vein CVC in adults with hematologic malignancies or germ cell tumors (including patients receiving autologous hematopoietic stem cell transplantation [ASCT]) with CHG were compared with non\u2010CHG dressings. The primary endpoint was <jats:italic>definite<\/jats:italic> CRBSI rate within 14\u2009days (dCRBSI14) of CVC insertion; secondary endpoints were combined rate of <jats:italic>definite<\/jats:italic> or <jats:italic>probable<\/jats:italic> CRBSI within 14\u2009days (dpCRBSI14), overall (dpCRBSI), and CRBSI incidences of all estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 2070 CVCs were assessed. There was no statistically significant difference in dCRBSI14 (2.3% vs. 3.5%) between patients with and without CHG gel dressings. Likewise, with regards to dpCRBSI14 (6.2% vs. 6.3%) and the overall dpCRBSI rate (9.2% vs. 10.5%), no significant difference was detected. Furthermore, dCRBSI14 incidence (2.0 vs. 3.2\/1000 CVC days), dpCRBSI14 incidence (5.4 vs. 5.6\/1000 CVC days), and overall CRBSI incidence (5.5 vs. 6.0\/1000 CVC days) showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRBSI rates were not reduced by the use of CHG gel dressings in patients with hematologic malignancies and\/or ASCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14098","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:07:41Z","timestamp":1694696861000},"page":"914-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chlorhexidine gluconate\u2010coated gel pad dressings for prevention of central venous catheter\u2010related bloodstream infections in patients with hematologic diseases or autologous stem cell transplantation: A registry\u2010based matched\u2010pair analysis"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-8060","authenticated-orcid":false,"given":"Daniel","family":"Teschner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Department of Hematology, and Medical Oncology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-7858","authenticated-orcid":false,"given":"Mirjeta","family":"Berisha","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Otto\u2010von\u2010Guericke University Magdeburg, Medical Faculty  Magdeburg 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