{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:06:39Z","timestamp":1784019999609,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Aim of this study was to retrospectively evaluate an interdisciplinary consultation followed by a precision\u2010based exercise program (PEP) for myeloma patients with stable and unstable bone lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of myeloma patients (<jats:italic>n<\/jats:italic>\u2009=\u2009100) who received a PEP according to an orthopedic evaluation were analyzed. Bone stability was assessed by established scoring systems (Spinal Instability Neoplastic Score [SINS], Mirels' score). All patients with stable and unstable osteolyses received a PEP and <jats:italic>n<\/jats:italic>\u2009=\u200991 were contacted for a follow\u2010up interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 60% of patients at least one osteolysis of the spine was considered potentially unstable or unstable. Following consultation, the number of patients performing resistance training could be significantly increased (\u22652 sessions\/week, 55%). Musculoskeletal pain was reported frequently. At the follow\u2010up interview, 75% of patients who performed PEP stated that painful symptoms could be effectively alleviated by exercise. Moreover, only patients who exercised regularly discontinued pain medication. No injuries were reported in association with PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We were able to demonstrate that individualized resistance training is implementable and safe for myeloma patients. By means of a PEP, patients' self\u2010efficacy in managing musculoskeletal pain was enhanced and pain medication could be reduced.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14106","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T09:06:18Z","timestamp":1695200778000},"page":"930-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A precision\u2010based exercise program for patients with multiple myeloma"],"prefix":"10.1111","volume":"111","author":[{"given":"Ulrike","family":"Dapunt","sequence":"first","affiliation":[{"name":"GMMG\u2010Study Group, Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Ehret","sequence":"additional","affiliation":[{"name":"GMMG\u2010Study Group, Department of Internal Medicine V Heidelberg University Hospital  Heidelberg 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