{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:32:13Z","timestamp":1787499133778,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune recovery following allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) decisively influences the occurrence of opportunistic infections, one of the leading causes of death among this group of patients. Yet, today, there are no laboratory parameters mirroring immune function sufficiently. Torque teno virus (TTV) has already proven itself as a functional immune marker in other settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this analysis, we investigated whether monitoring of TTV\u2010DNA load in whole blood is able to provide additional information on the capacity of the immune system to control cytomegalovirus (CMV) replication in allo\u2010HSCT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Whole blood samples from 59 patients were collected upon allo\u2010HSCT (between Day \u22127 and +10), on Day +14, +21, +28, +56, +90, and +365 post\u2010transplant. TTV\u2010DNA loads and other relevant clinical information were correlated with the risk of CMV infections or reactivations, defined by evidence of viral replication in blood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CMV serostatus of the recipient and a TTV load below 1000 copies\/mL upon allo\u2010HSCT were significantly associated with an increased incidence of CMV infection or reactivation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quantification of TTV load in the early phase of allo\u2010HSCT procedure could provide additional information in order to identify patients at risk for CMV infection or reactivation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14111","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:18:02Z","timestamp":1695968282000},"page":"963-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>Torque teno virus\u2010DNA<\/scp>\n                    load as individual\n                    <scp>cytomegalovirus<\/scp>\n                    risk assessment parameter upon allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-1257","authenticated-orcid":false,"given":"Arlene","family":"Spiertz","sequence":"first","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-3614","authenticated-orcid":false,"given":"Anastasia","family":"Tsakmaklis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-0038","authenticated-orcid":false,"given":"Fedja","family":"Farowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"German Center for Infection Research (DZIF), Partner Site Bonn\u2010Cologne University of Cologne  Cologne Germany"},{"name":"Department of Internal Medicine, Infectious Diseases Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-3026","authenticated-orcid":false,"given":"Elena","family":"Knops","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-5139","authenticated-orcid":false,"given":"Eva","family":"Heger","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8309-6207","authenticated-orcid":false,"given":"Maike","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-2548","authenticated-orcid":false,"given":"Rolf","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-0257","authenticated-orcid":false,"given":"Udo","family":"Holtick","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0446-3224","authenticated-orcid":false,"given":"Maria J. 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